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Imaging of Adipose Tissue in Bone and Muscle: Implications for Osteoporosis, Sarcopenia and Frailty
The quantitative assessment of adipose tissue in bone and muscle is of increasing interest in musculoskeletal research and routine in relation to osteoporosis, sarcopenia, fractures, over-/under-nutrition states, as well as frailty. However, imaging approaches to assess myosteatosis and bone marrow adipose tissue (BMAT) are still challenging, i.e., different fat depots (intermuscular, intramuscular, and intramyocellular fat) may represent different risk factors to metabolic health and muscle function but the segmentations of muscle and adipose tissue vary significantly, and MRI (the reference imaging tool for BMAT) faces challenges in the accuracy and precision of BMAT quantification. In addition, the studies of BMAT fatty acid composition in vivo are growing interests but limited by the estimation accuracy of advanced imaging methods like Magnetic Resonance Spectroscopy or chemical shift encoding-based water-fat imaging (WFI) techniques. Furthermore, identifying the effects of adipose tissue on bone and muscle would give new insights into the pathophysiology of sarcopenia, osteoporosis and frailty and also improve our understanding of intervention.
Bone Marrow Adiposity: Establishing Harmonized, Mechanistic and Multidisciplinary Approaches to Reach Clinical Translation
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Aging Skeleton
The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. - Covers all aspects of the aging skeleton in one comprehensive volume - Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass - Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton - Reviews current therapeutic approaches and methods - Written by internationally renowned authors and edited by leaders in the field - Is the only book available on this subject
Kinase Drug Discovery
Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experie...
Brinkman's cumulatieve catalogus van boeken
Voorts een alphabetische lijst van Nederlandsche boeken in België uitgegeven.
Secondary Fracture Prevention
Secondary Fracture Prevention: An International Perspective presents practitioners and academic clinicians with a better understanding of secondary fracture prevention and models of care from a variety of settings and countries. This must-have guide provides practitioners and academic clinicians with essential information about this broad clinical and research topic that extends across the globe. Preventing secondary fractures starts with assessing what works and what does not work, reviewing major society guidelines, and what workup and management is necessary. This book reviews these topics and provides the rationale for pursuing a workup to prevent fractures in this patient population.
How to Read a Novel
"Do we still know how to read a novel?" John Sutherland, Chairman of the 2005 Booker Prize Committee, asks. His disheartened answer is an unequivocal, "No." But Sutherland has not given up hope. With acerbic wit and intellect, he traces the history of what it used to mean to be well-read and tells readers what it still means today. Using this delightful book as a means to an end, he reminds readers how the delicate charms of fiction can be at once wonderful and inspired and infuriating. On one level this is a book about novels: how they work, what they're about, what makes them good or bad, and how to talk about them. At a deeper level, this is a book in which one of the most intimate tête-...
