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Continued Fascination – A Tribute to a Giant in Immunology, Dr. William E. Paul
Dr. William E. Paul (1936–2015) was the leader of the National Institutes of Health (NIH) immunology community and his career is without parallel in the field of immunology. He was the Chief of the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), from 1970 at the age of 34 until his death. His groundbreaking contributions to the field of immunology, including the discovery of interleukin (IL)-4, led to more than 600 publications over half a century. He also played an important role in the establishment of the NIH Vaccine Research Center while he was the Director of the NIH Office of AIDS Research. Furthermore, Dr. Paul was a shining icon and an inter...
Case Studies in Immunology: X-linked Hypohydrotic Ectodermal Dysplasia and Immunodeficiency
This case study is about a nine-month infant with X-linked ectodermal dysplasia and immunodeficiency due to NEMO deficiency. It provides insights on immunodeficiency due to a defective component in an intracellular signaling pathway required for both innate and adaptive immunity.
Case Studies in Immunology: Omenn Syndrome
This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
Case Studies in Immunology: Interleukin 1 Receptor-associated Kinase 4 Deficiency
This case study is about a 6-year-old boy with recurrent pneumococcal meningitis. It provides information on an inability of the innate immune system to detect pathogen presence, and the sequencing of DNA for the IRAK4 gene that revealed a homozygous nonsense mutation within the kinase domain.
Case Studies in Immunology: Adenosine Deaminase Deficiency
This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
Case Studies in Immunology: T-Cell Lymphoma
This book presents a case history of a patient with T-Cell lymphoma, to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is intended for medical students and pre-medical students.
Case Studies in Immunology: Wiskott-Aldrich Syndrome
This book presents a case history of a patient with Wiskott-Aldrich syndrome to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is intended to help medical students and pre-medical students.
Case Studies in Immunology: Hereditary Periodic Fever Syndromes
This case study is about fever and inflammation in the absence of infection in an infant, a week after his birth. One of the most serious long-term complications of the periodic fever syndromes is systemic amyloidosis, which occurs when misfolded fragments of serum amyloid get deposited in tissues.
Case Studies in Immunology: Hereditary Angioneurotic Edema
This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
Case Studies in Immunology: Myasthenia Gravis
This case study illustrates the features of a common type of myasthenia gravis, which is observed in older people and is called the oculobulbar form because it principally involves the muscles of the eye. Abnormalities of the thymus are not observed in older patients and thymectomy does not help.
