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Genetics of Epilepsy and Genetic Epilepsies
This volume provides updated information on epilepsy genes, on the clinical picture of genetic epilepsies discovered so far, and on conceptual advances in the complicated area of genotype-phenotype correlations. Recent studies on monogenic epilepsies present new insights into mechanisms whereby a mutation of a single gene, coding for an ion channel, can result in a complex epileptic phenotype. The analysis of genetically-determined epileptogenic dysplasia is advancing our understanding of the role of genes in controlling normal and pathological brain development. The pathogenic mechanisms by which gene mutations determine progressive myoclonus epilepsies offer critical opportunities to understand the role of genetic factors in neurodegenerative phenome-na associated with an even broader range of progressive epilepsy types. The specialists who have contributed to this book are outstanding international experts in their respective fields, ensuring first and foremost that the reviews are of relevance to clinicians dealing with epilepsy in their daily practice, as well as providing the highest quality scientific information for biomedical research.
Giacomo Puccini
Opera recordings have been with us since the creation of the first wax cylinders. Now at a time when the 25-year reign of the compact disc appears to be coming to an end is the moment to take stock of the history of recordings of arguably the most popular composer of operas, Giacomo Puccini. In Giacomo Puccini: A Discography, librarian and music historian Roger Flury looks at each opera chronologically from Le Villi to Turandot, followed by sections on Puccini's instrumental, chamber, orchestral, and solo vocal works. Details of each complete opera are listed by recording date, followed by excerpts in the order in which they occur in the opera. Recordings of each aria are listed alphabetical...
Multidisciplinary Approaches to Neural Computing
This book presents a collection of contributions in the field of Artificial Neural Networks (ANNs). The themes addressed are multidisciplinary in nature, and closely connected in their ultimate aim to identify features from dynamic realistic signal exchanges and invariant machine representations that can be exploited to improve the quality of life of their end users. Mathematical tools like ANNs are currently exploited in many scientific domains because of their solid theoretical background and effectiveness in providing solutions to many demanding tasks such as appropriately processing (both for extracting features and recognizing) mono- and bi-dimensional dynamic signals, solving strong no...
Epilepsy Towards the Next Decade
A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0.5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy and the approval of several new antiepileptic drugs, about 30% of patients continue to experience recurrent seizures which are medically, physically, and/or socially disabling. The editor of this volume hopes that by bridging the gap between the fundamental biology of epilepsy and its clinical implications he might spur further research and treatment options.
Italian American Experience in New Haven, The
Using interviews and photographs, Anthony Riccio provides a vital supplement to our understanding of the Italian immigrant experience in the United States. In conversations around kitchen tables and in social clubs, members of New Haven's Italian American community evoke the rhythms of the streets and the pulse of life in the old ethnic neighborhoods. They describe the events that shaped the twentieth century—the Spanish Flu pandemic, the Great Depression, and World War II—along with the private histories of immigrant women who toiled under terrible working conditions in New Haven's shirt factories, who sacrificed dreams of education and careers for the economic well-being of their families. This is a compelling social, cultural, and political history of a vibrant immigrant community.
The Complicity of Friends
The Complicity of Friends offers an entirely original perspective within which to appreciate four eminent Victorians: Herbert Spencer, George Eliot, G. H. Lewes, and John Hughlings-Jackson. For the first time, I clarify the nature of Spencer's illness and demonstrate its repercussions in the lives and work of his three gifted friends.
The Oxford Handbook of Synesthesia
Synesthesia is a fascinating phenomenon which has captured the imagination of scientists and artists alike. This title brings together a broad body of knowledge about this condition into one definitive state-of-the-art handbook.
