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Genetics of Epilepsy and Genetic Epilepsies
This volume provides updated information on epilepsy genes, on the clinical picture of genetic epilepsies discovered so far, and on conceptual advances in the complicated area of genotype-phenotype correlations. Recent studies on monogenic epilepsies present new insights into mechanisms whereby a mutation of a single gene, coding for an ion channel, can result in a complex epileptic phenotype. The analysis of genetically-determined epileptogenic dysplasia is advancing our understanding of the role of genes in controlling normal and pathological brain development. The pathogenic mechanisms by which gene mutations determine progressive myoclonus epilepsies offer critical opportunities to understand the role of genetic factors in neurodegenerative phenome-na associated with an even broader range of progressive epilepsy types. The specialists who have contributed to this book are outstanding international experts in their respective fields, ensuring first and foremost that the reviews are of relevance to clinicians dealing with epilepsy in their daily practice, as well as providing the highest quality scientific information for biomedical research.
Epilepsy and Neurodevelopmental Diseases
This topic has been realized in collaboration with Dr. Gabriele Ruffolo, Post Doctoral Researcher at the University of Rome (Sapienza) (ORCID ID: 0000-0002-6554-5496).
The Causes of Epilepsy
Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Multidisciplinary Approaches to Neural Computing
This book presents a collection of contributions in the field of Artificial Neural Networks (ANNs). The themes addressed are multidisciplinary in nature, and closely connected in their ultimate aim to identify features from dynamic realistic signal exchanges and invariant machine representations that can be exploited to improve the quality of life of their end users. Mathematical tools like ANNs are currently exploited in many scientific domains because of their solid theoretical background and effectiveness in providing solutions to many demanding tasks such as appropriately processing (both for extracting features and recognizing) mono- and bi-dimensional dynamic signals, solving strong no...
Epilepsy Towards the Next Decade
A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0.5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy and the approval of several new antiepileptic drugs, about 30% of patients continue to experience recurrent seizures which are medically, physically, and/or socially disabling. The editor of this volume hopes that by bridging the gap between the fundamental biology of epilepsy and its clinical implications he might spur further research and treatment options.
The Cronaca Di Partenope
This volume offers the first critical edition of and thorough introduction to one of medieval Naples’ most notable expressions of local memory and identity and a foundational text in the subsequent development of Neapolitan historiography.
The Complicity of Friends
The Complicity of Friends offers an entirely original perspective within which to appreciate four eminent Victorians: Herbert Spencer, George Eliot, G. H. Lewes, and John Hughlings-Jackson. For the first time, I clarify the nature of Spencer's illness and demonstrate its repercussions in the lives and work of his three gifted friends.
Sudden Death in Epilepsy: Basic and Translational Research
Sudden Death in Epilepsy (SUDEP) is a major cause of death in people with epilepsy, accounting for up to 17% of all deaths. Research interest is exploding, focusing on epidemiology, basic mechanisms, identification of risk factors, and biomarkers. New wearable technologies are approved or in development. These incorporate accelerometers and advanced heart rate detection, which are linked to smart phones. The advent of FDA approved detection devices now allows immediate intervention by family and loved ones. The next frontier for SUDEP remains effective prevention strategies, which will likely include new devices and pharmacologic interventions. This volume is organized into three sections: Basic and Physiologic Mechanisms; Clinical Risk Factors and Inventories; and Very Early Research into Pharmacologic Interventions. It is our hope that this eBook will inform clinicians of key advances in the field, and to foster and stimulate basic and translational research with one purpose: To prevent SUDEP in those at risk.
The Oxford Handbook of Synesthesia
Synesthesia is a fascinating phenomenon which has captured the imagination of scientists and artists alike. This title brings together a broad body of knowledge about this condition into one definitive state-of-the-art handbook.
