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The Tumor Microenvironment
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and...
The First Family
Before Al Capone and Lucky Luciano, there was the one-fingered, cunning Giuseppe Morello and his murderous coterie of brothers. Had it not been for Morello, the world may never have heard of 'men of honour', the code of omertaor Mafia wars. This explosive book tells the story of the first family of New York, and how this extended close-knit clan of racketeers and murderers left the backwaters of Sicily to successfully establish themselves as the founding godfathers of the New World. First Family will explain in thrilling, characterful detail how the American Mafia established itself so successfully. Combining strong narrative and raw violence - set against the raucous bustle of early twentieth-century New York, and the impoverished rural life of nineteenth-century Sicily - this impeccably researched, groundbreaking study of a crucial period of American history is a compelling portrait of the early years of organised crime.
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Obesity, Type 2 Diabetes and the Adipose Organ
This richly illustrated book provides a detailed description of the gross anatomy, light microscopy, immunohistochemistry, and electron microscopy of the adipose organ, which comprises subcutaneous and visceral fat depots. Findings in mice of differing genetic backgrounds (obesity prone and resistant) and maintained in standard and various physiologic and pathologic conditions are presented. The latter conditions include chronic cold exposure, warm exposure, fasting, pregnancy–lactation, and obesity. Features of the fetal adipose organ are described in a separate chapter, and results from transgenic mice are also presented when relevant. The human adipose organ is addressed in several chap...
The Occult Mind
"Given the historical orientation of philosophy, is it unreasonable to suggest a wider cast of the net into the deep waters of magic? By encountering magical thought as theory, we come to a new understanding of a thought that looks back at us from a funhouse mirror."-from The Occult Mind Divination, like many critical modes, involves reading signs, and magic, more generally, can be seen as a kind of criticism that takes the universe-seen and unseen, known and unknowable-as its text. In The Occult Mind, Christopher I. Lehrich explores the history of magic in Western thought, suggesting a bold new understanding of the claims made about the power of various belief systems. In closely interlinke...
Beauty, Devotion and Spirituality
There is scant research on the art produced under the Congregation of the Oratory of Saint Philip Neri, with the exception of a couple of general books focused primarily on major Oratorian art pieces. Therefore, this book of essays aims to discuss the art and culture produced by or associated with the Oratorians by providing a broad overview focused especially on rarely investigated issues. The authors focus on this very important artistic production, commonly forgotten when compared with other religious productions of art, by covering geographical areas spanning from Sri Lanka to Mexico, including Italy, Spain, the United Kingdom, India and Brazil.
