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Hedgehog-Gli Signaling in Human Disease
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Molecular and Cellular Methods in Developmental Toxicology
This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.
Plastic Reason
Throughout the twentieth century, neuronal researchers knew the adult human brain to be a thoroughly fixed and immutable cellular structure, devoid of any developmental potential. Plastic Reason is a study of the efforts of a few Parisian neurobiologists to overturn this rigid conception of the central nervous system by showing that basic embryogenetic processesÑmost spectacularly the emergence of new cellular tissue in the form of new neurons, axons, dendrites, and synapsesÑcontinue in the mature brain. Furthermore, these researchers sought to demonstrate that the new tissues are still unspecific and hence literally plastic, and that this cellular plasticity is constitutive of the possibility of the human. Plastic Reason, grounded in years of fieldwork and historical research, is an anthropologistÕs account of what has arguably been one of the most sweeping events in the history of brain researchÑthe highly contested effort to consider the adult brain in embryogenetic terms. A careful analysis of the disproving of an established truth, it reveals the turmoil that such a disruption brings about and the emergence of new possibilities of thinking and knowing.
50 Years Of Singapore-europe Relations: Celebrating Singapore's Connections With Europe
As Singapore enters its 50th year of independence, it is a good time to reflect on its past as well as look to the future. 50 Years of Singapore-Europe Relations: Celebrating Singapore's Connections with Europe is one such contribution to the wide collection of books commemorating Singapore's 50th birthday. The essays and articles in this edited volume capture historical moments, reveal the heartfelt wishes and thoughtful comments of Europeans who have made Singapore their home, chronicle some of the long-standing partnerships and ponder the future challenges of Singapore.This unique book contains a wide range of essays and articles reflecting on the strong connections that Singapore enjoys ...
Book Nooks
Home is where the books are. This inspiring home decor book is brimming with photos of cozy places to read and creative ways to display books at home. For stylish bookworms and bookish stylists, this covetable home décor book merges the literary appeal of Jane Mount’s bestselling Bibliophile with the aspirational allure of Emily Henderson’s bestselling Styled. Discover beautiful bookshelves adorned with lovely objets d’art, handsome home libraries with snug armchairs, reading areas for kids that ignite the imagination, and cookbook corners in quaint kitchens—and learn to replicate these in your own space. From bedside tables to bar carts, leather-bound collections to color-coded she...
Hedgehog Signaling
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hedgehog signaling. Contributions from leading authorities Informs and updates on all the latest developments in the field
Progenitor Diversity and Neural Cell Specification in the Central Nervous System
The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specializatio...
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Postimplantation Development in the Mouse
Examines the establishment of the germ layers and other cell lineages in the early embryo including details of cell movements during the beginning stages of primitive streak formation. Discusses patterns of gene expression during the development of such tissues as the limb bud, skeletal, muscle and the central nervous systems placing special emphasis on commitment to particular cell types. Although it concentrates on the mouse as an example of mammalian development--chick, amphibian and Drosophila embryogenesis are employed whenever these organisms are more applicable to the study of a particular problem.
