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Translation and Its Regulation in Cancer Biology and Medicine
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the transla...
Science
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El acertijo de la vida
El acertijo de la vida es una fascinante narración de los hallazgos más importantes de la Biología durante el siglo XX y su revolución para dar paso a la genética. Para ello da cuenta de los actores más importantes en este proceso y el contexto en el que se dieron sus aportaciones: la importancia que tuvo Rosalind Franklin en el desarrollo del esquema de la doble hélice del ADN, las primeras ideas en la biología relacionadas a la búsqueda del gen y que dieron paso a la genética, el descubrimiento del ADN, el cambio de mentalidad en los biólogos que estudiaban los genes, quienes pasaron de percibir a éstos como unidades químicas a unidades de información (ello debido a un contex...
Translational Research in Breast Cancer
This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
Renal Cell Carcinoma
The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors. Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.
Translational Control
A comprehensive account of recent research in translational control and the molecular mechanisms involved, focusing on the numerous control mechanisms observed in eukaryotes. Subjects include basic mechanisms; the role of phosphorylation; regulation by trans-acting proteins; effects of viral infection; and mRNA stability. Other topics include translational control mediated by upstream AUG codons; a comparative view of initiation site selection mechanisms; and genetics of mitochondrial translation. For researchers with interests in gene expression, RNA biology, and protein synthesis. Annotation copyright by Book News, Inc., Portland, OR
Balancing Acts
Balancing Acts presents an iterative, democratic, and inclusive approach to social change that is suited to the complexities of the twenty-first century.
Barr's The Human Nervous System: An Anatomical Viewpoint
This classic well-illustrated textbook simplifies neuroscience content to focus coverage on the essentials and helps students learn important neuroanatomical facts and definitions. Among its many distinctions are its organization by region and then pathways into and out of the nervous system, which permits students an integrated view of the anatomy and physiology; level of treatment suited to increasingly shorter neuroanatomy course hours for medical and allied health students; and the author's succinct writing style.
