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Case Reports in Hematological Malignancies : 2022
This Research Topic aims to collect all the Case Reports submitted to the Hematological Malignancies section. All the Case Reports submitted to this collection will be personally assessed by a senior Associate Editor before the beginning of the peer-review process. Please make sure your article adheres to the following guidelines before submitting it.
Neurogenic Inflammation
Take advantage of this unique book - the first single-volume resource to explore all important aspects of neurogenic inflammation. An unrivaled compilation of up-to-date information, Neurogenic Inflammation contains chapters written by recognized authorities in their areas of expertise. It covers the basic mechanisms and the pathophysiological implications of neurogenic inflammatory processes and points to novel therapeutic strategies in the field of inflammatory and related diseases. The book highlights the many systems and mechanisms involved in neurogenic inflammation, including vasodilatation, plasma extravasation, leukocyte adhesion, smooth muscle contraction, exocrine gland secretion, and recruitment of inflammatory cells. The authors discuss the contribution of neurogenic inflammation to human diseases, such as migraine, asthma, arthritis, and inflammatory bowel disease, linked to the ubiquitous distribution of sensory nerves to organs and tissues at both the somatic and visceral level. Neurogenic Inflammation is the clear choice for a one-step, authoritative guide to the latest developments in this dynamic field.
TRP Channels as Therapeutic Targets
TRP Channels as Therapeutic Targets, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. The Editor lined up a team of worldwide experts in academia and corporate R&D to provide diverse views into these promising drug development targets. Following the research development happened in the past ten years, since the first edition published, the revision includes seven new chapters. All remaining chapters are completely updated. New topics included in the book are TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of...
Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
This book is a printed edition of the Special Issue "Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts" that was published in Pharmaceuticals
Advances in Pharmacology
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Progress in Medicinal Chemistry
The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appear...
Strigolactones, Alkamides and Karrikins in Plants
Strigolactones, Alkamides and Karrikins in Plants: Recent Updates and Future Prospects provides comprehensive knowledge on the various aspects of plant growth, physiology, and communication associated with the three potential biomolecules. Strigolactones have gained much importance in the last decade as potential plant growth regulators. Likewise, alkamides are also known for their plant growth regulatory and pharmacological properties. The evolutionary significance of karrikins as a potential signaling molecule in different plant groups has been fascinating to plant physiologists and ecologists. This book enables the reader to gain insights into the myriad role of these biomolecules in plan...
Vanilloid Receptor TRPV1 in Drug Discovery
Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it "the holy grail" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arth...
Highly Selective Neurotoxins
Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.
