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The Placenta and Human Developmental Programming
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Biology and Pathology of Trophoblast
Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.
The Orphans
Three abandoned orphans in New York find themselves thrown together, and in the process, bring together three separate worlds. They discover a country riddled with spell-casting elves, war-mongering Cyclopes, hidden kingdoms, stolen thrones, and centuries of war. While the three struggle to grow and change, they also transform the worlds around them, breaking age-old hatreds and ushering in new levels of acceptance, trust, and peace. Derek, born a Cyclops with his single eye, lives a solitary life until the young, talkative elf named Ferris, joins him in the orphanage. Restless for change, the Cyclops and elf escape their limited lives for new freedom. When their lives are threatened their freedom demands things of them they never dreamed. Secrets are revealed and trust tested as they decide who is friend and who is foe - the stubborn girl who once wanted to hurt them, the elf king who wanted to tear the three apart, or the revolutionary hoard of Cyclopes? The Orphans is a story for everyone who struggles to be accepted, longs to be loved, and desires to change their world.
The Compatibility Gene
There are far-reaching consequences of the way our body has evolved to fight disease. This book describes how genes link our struggle with disease to compatibility with others, the wiring of our brain, and success in pregnancy.
IVF and Assisted Reproduction
This is the first transnational history of IVF and assisted reproduction. It is a key text for scholars and students in social science, history, science and technology studies (STS), cultural studies, and gender and sexuality studies, and a resource for journalists, policymakers, and anyone interested in assisted reproduction. IVF was seen as revolutionary in 1978 when the first two IVF babies were born, in the UK and India. Assisted reproduction has now contributed to the birth of around ten million people. The book traces the work of IVF teams as they developed new techniques and laid the foundations of a multi-billion-dollar industry. It analyses the changing definitions and experience of...
The Placenta and Human Developmental Programming
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Serafino Zappacosta and the Ceppellini School: A Pioneer Model For Nurturing Education in Immunology
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Pre-eclampsia
This book reviews the research in pre-eclampsia and the practical management of this common and life-threatening disorder.
How to Prepare the Endometrium to Maximize Implantation Rates and IVF Success
Practical, evidence-based review of all factors that can affect the endometrium and influence implantation success rates.
Establishing Medical Reality
Medicine raises numerous philosophical issues. This volume approaches the philosophy of medicine from the broad naturalist perspective. This holds that philosophy must be continuous with, constrained by, and relevant to empirical results of the natural and social sciences. The upshot is a unique volume that ties medicine to contemporary issues in philosophy of science and metaphysics.
