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Obesity and Lipotoxicity
Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
Protein Kinase-mediated Decisions Between Life and Death
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Endothelium
The function and life span of endothelial cells have a large impact upon the quality and expectancy of an individual's life. During low perfusion, the adaptation of different cells to hypoxia precipitate the aggressive progression of diseases. Although the clinical studies have convincingly shown that endothelial dysfunction occurs whenever the biological functions or bioavailability of nitric oxide are impaired, in all these scenarios, the role of endothelial cell-destructive process cross-talk is yet poorly understood. This book focuses on the contribution of molecular mechanisms to endothelial dysfunction in related metabolic disorders.
Dil ve Edebiyat Eğitiminde Yenilikçi Araçlar ve Kullanımları
Çağdaş dünyanın eğitim anlayışında yeni bir dönem açılıyor. Bugün sosyal bilimlerin tüm alanları gibi dil ve edebiyat öğretiminde de teknolojik gelişimin yanında, covid-19 salgınından dolayı teknolojiye adaptasyonun da hızlanması yeni bir döneme girdiğimizi daha net görmemizi sağlıyor. Ancak ülkemizin ilköğretim, ortaöğretim ve yükseköğretim kurumlarının büyük bölümünde, dil ve edebiyat öğretiminde hâlâ geleneksel yöntemlerin tercih edildiğini görmekteyiz. 20. yüzyılın başından itibaren teknoloji üreten toplumlar, bilimde ve eğitimde atılım gerçekleştirdiler. Bugün dünya, 4. sanayi devrimini, yapay zekâ uygulamalarını, farkl...
Tryptophan Metabolism: Implications for Biological Processes, Health and Disease
This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.
The Oxford Handbook of Ancient Anatolia
This title provides comprehensive overviews on archaeological philological, linguistic, and historical issues at the forefront of Anatolian scholarship in the 21st century.
The Fountain of Woof
What is the Fountain of Woof? In this first-of-a-kind book for dogs and their people, Dr. Franklin Utchen, a small animal veterinarian with over 35 years of experience in daily practice, helps answer that question. Based on exhaustive research in dogs, humans, mice, and more, he details the leading-edge knowledge about the science of longevity as it applies to our dogs. Dr. Utchen explains in common terms why an animal ages and discusses the simple “longevity” meds that a pet caretaker can start giving today to help a dog live his or her life as long and healthy as possible. If you want to know the latest information about how to help an old dog live younger, and a young dog live younger longer, then this book is for you and your pup.
Hittite Landscape and Geography
Hittite Landscape and Geography provides a holistic geographical perspective on the study of the Late Bronze Age Hittite Civilization from Anatolia (Turkey) both as it is represented in Hittite texts and modern archaeology.
The Note from Heaven
Githa Ben-David presents a method for liberating the natural voice using regressive cell singing - one of the most direct ways to get in contact with the subconscious mind. This liberation has a healing effect on body and soul and can be experienced by every speaking person. With inspiration from India, Githa has put together a program for self-study, along with a practice instruction program that can be downloaded. Utilising this method you will 'sing yourself free from traumas that have their origin in this life, the womb or previous lifetimes. In regressive cell singing, The Note from Heaven is used as a tuning fork to retune cells to their former harmony. Any notes, sounds or outbursts that genuinely express The Note from Heaven can release blocked energy imprisoned in the Singer?s body as trauma. The process starts a cell-dance, which reorganizes the body back to it's original balanced matrix. Transform your life through the power of sound. In the beginning there was sound. With sound everything was created. You are sound.
