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An Introduction to the Planning Domain Definition Language
Planning is the branch of Artificial Intelligence (AI) that seeks to automate reasoning about plans, most importantly the reasoning that goes into formulating a plan to achieve a given goal in a given situation. AI planning is model-based: a planning system takes as input a description (or model) of the initial situation, the actions available to change it, and the goal condition to output a plan composed of those actions that will accomplish the goal when executed from the initial situation. The Planning Domain Definition Language (PDDL) is a formal knowledge representation language designed to express planning models. Developed by the planning research community as a means of facilitating ...
Transfer Learning for Multiagent Reinforcement Learning Systems
Learning to solve sequential decision-making tasks is difficult. Humans take years exploring the environment essentially in a random way until they are able to reason, solve difficult tasks, and collaborate with other humans towards a common goal. Artificial Intelligent agents are like humans in this aspect. Reinforcement Learning (RL) is a well-known technique to train autonomous agents through interactions with the environment. Unfortunately, the learning process has a high sample complexity to infer an effective actuation policy, especially when multiple agents are simultaneously actuating in the environment. However, previous knowledge can be leveraged to accelerate learning and enable s...
Acadian Descendants
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Probabilistic Databases
Probabilistic databases are databases where the value of some attributes or the presence of some records are uncertain and known only with some probability. Applications in many areas such as information extraction, RFID and scientific data management, data cleaning, data integration, and financial risk assessment produce large volumes of uncertain data, which are best modeled and processed by a probabilistic database. This book presents the state of the art in representation formalisms and query processing techniques for probabilistic data. It starts by discussing the basic principles for representing large probabilistic databases, by decomposing them into tuple-independent tables, block-in...
Transcription Factors and Human Disease
Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that pa...
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The Legend of the Corrib King
A cryptic poem precludes mysterious and suspenseful tour of the countryside.
The Social Determinants of Mental Health
The Social Determinants of Mental Health aims to fill the gap that exists in the psychiatric, scholarly, and policy-related literature on the social determinants of mental health: those factors stemming from where we learn, play, live, work, and age that impact our overall mental health and well-being. The editors and an impressive roster of chapter authors from diverse scholarly backgrounds provide detailed information on topics such as discrimination and social exclusion; adverse early life experiences; poor education; unemployment, underemployment, and job insecurity; income inequality, poverty, and neighborhood deprivation; food insecurity; poor housing quality and housing instability; a...
Protein Metabolism and Homeostasis in Aging
Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised fa...
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