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CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels
Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several varia...
The Angel of the Crows
This is not the story you think it is. These are not the characters you think they are. This is not the book you are expecting. London 1888. Angels inhabit every public building, and vampires and werewolves walk the streets with human beings in a well-regulated truce. A utopia, except for one thing: Angels can Fall, and that Fall is like a nuclear bomb in both the physical and metaphysical worlds. Dr J. Doyle returns to London having been wounded in Afghanistan by a Fallen, and finds himself lodging in Baker Street with the enigmatic angel Crow. But living with a rogue angel is not so easy; the pair find themselves drawn into the supernatural and criminal worlds of London, from a man kidnapped by a vampire nest to Jack the Ripper's horrific murders. Besides Doyle's nightmares, there is the lingering worry that Crow might Fall... “The Angel of the Crows is an entertaining ride–a compelling fantasy mystery set in an alternate but startlingly familiar Victorian London. You’ve been here before–not.” –Tim Powers “This tale takes flight in ways that are dark and rich and wholly unexpected. Quite simply, I loved it.” –John Scalzi
Congressional Record Index
Includes history of bills and resolutions.
The Mist in the Mirror
For the last twenty years Sir James Monmouth has been a gentleman adventurer, journeying all over the globe in the footsteps of his hero, the great pioneering traveller Conrad Vane. One rainy winter night, Sir James returns to London. Orphaned at five, it is now time to find out more about his family and origins, and also to learn about the early years of Conrad Vane. But at every turn James is warned off his investigation into Conrad Vane. Do these warnings explain his flashes of intense fear and feelings of being watched? And what of the boy who has started haunting his every step and the mysterious mirror with its inexplicable reflections? Eventually, Sir James's quest leads him to the old lady of Kittiscar Hall, and deep into a past that binds him to his hero in ways he never could have imagined.
Congressional Record
The Congressional Record is the official record of the proceedings and debates of the United States Congress. It is published daily when Congress is in session. The Congressional Record began publication in 1873. Debates for sessions prior to 1873 are recorded in The Debates and Proceedings in the Congress of the United States (1789-1824), the Register of Debates in Congress (1824-1837), and the Congressional Globe (1833-1873)
Tom Swift and His Flying Lab
Tom Swift and his father travel to a South American country in their flying space lab to look for uranium and keep it from falling into the hands of a group of dangerous rebels.
