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Folia Biologica
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Self-Assembled Molecules – New Kind of Protein Ligands
The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. This book is an open access under a CC BY license.
Air Pollution as a Risk Factor Affecting Human Health and Economic Costs
According to the World Health Organization air pollution is one of the most important environmental risk to health, influencing the burden of disease such as stroke, heart disease, lung cancer but also chronic and acute respiratory diseases, including bronchial asthma. For years, WHO has also been alarming about the enormous number of premature deaths that are attributed each year to exposure to air pollution. It is estimated that air pollution is responsible for over 7 million human lives, of which over 4 million are attributed to the exposure to ambient (outdoor) air pollutants. Therefore, it is a leading factor determining the global scale of morbidity and mortality not only due to serious diseases of the cardiovascular and respiratory systems or neoplastic diseases, but also significantly affects the reduced quality of life, usually associated with disability caused by chronic disease.
Folia Biologica
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