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Small Molecule Therapeutics for Schizophrenia
The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.
Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework
This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia. The work on cognition in schizophrenia from the past 20 years is highlighted, and emphasis throughout the book is placed on utilizing the Research Domain Criterion framework. Thus, the book also covers animals work relevant to schizophrenia that assesses behaviors utilizing the same framework, enabling mechanistic studies and highlighting potential biomarkers of function. The book also includes important areas of research in the field of cognitive function in schizophrenia that have received less attention, such as cognitive side-effects of current treatments and olfactory-based cognition. Altogether, the book provides a translational perspective of the most-up-to-date research on cognition in schizophrenia to-date, but with identification of novel directions for research initiatives..
Fear Extinction
This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acq...
Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder and Its Treatment
In this volume there is a strong emphasis on translational science, with preclinical approaches suggesting new directions for development of new treatments. Individual chapters describe how neuroimaging, neuroendocrine, genetic and behavioral studies use powerful research tools that are offering a completely new understanding of the factors that increase vulnerability to ADHD. The clinical impact of co-morbid problems, especially obesity and substance misuse, are highlighted and explain what such problems can tell us about the etiology of ADHD, more generally. Reviews of the pharmacology of established drug treatments for ADHD justify an exciting novel theory for their therapeutic actions and address questions about the effects of their long‐term use.
Virtual Reality in Behavioral Neuroscience: New Insights and Methods
Virtual Reality (VR) is a rapidly maturing technology that offers new and unique solutions to otherwise intractable problems in the study of cognition, behavior and neuroscience. VR removes many of the constraints imposed by laboratory paradigms, allowing us to track cognitive, behavioral and brain responses to naturalistic (or even impossible) situations without sacrificing experimental control. But VR is not a tool that can be swiftly and effortlessly integrated into existing research pipelines; currently, the benefits of VR are accompanied by a host of methodological challenges and important practical considerations. To help navigate this new methodology, this volume provides a balanced r...
Behavioral Pharmacology of the Cholinergic System
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Neuroscience of Social Stress
Social stress has emerged as a research front in the neurosciences, and this volume highlights recent insights in brain mechanisms and methodological advances. The topics range from the evolutionary origins of coping with social challenges to neural mechanism-driven focus on novel treatment targets. The parallel presentation of work with animal models and human subjects is bound to be useful to a broad research community.
The Functional Roles of Histamine Receptors
Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and it...
The Neurobiology of Childhood
During the past years there has been rapid progress in the understanding of how early life stress impacts psychopathology in children. The first two parts of this book present the basic principles of brain development and describe the most important neuronal systems. This includes systems involved in emotion processing, cognitive control, and social processes. These first two general sections are followed by an overview about recent research on various neuronal and psychiatric disorders, where environmental exposures and altered brain development play an important role: sleep, autism, ADHD and other developmental forms of psychopathology.
