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Biobetters
  • Language: en
  • Pages: 384

Biobetters

  • Type: Book
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  • Published: 2015-08-21
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  • Publisher: Springer

“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor produc...

Analysis of Aggregates and Particles in Protein Pharmaceuticals
  • Language: en
  • Pages: 480

Analysis of Aggregates and Particles in Protein Pharmaceuticals

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

Economic Dimensions of Personalized and Precision Medicine
  • Language: en
  • Pages: 361

Economic Dimensions of Personalized and Precision Medicine

Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability an...

Biophysics for Therapeutic Protein Development
  • Language: en
  • Pages: 299

Biophysics for Therapeutic Protein Development

This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.

Analytical Ultracentrifugation
  • Language: en
  • Pages: 617

Analytical Ultracentrifugation

Analytical Ultracentrifugation, the latest volume in Methods in Enzymology, focuses on analytical ultracentrifugation. The scope of this technique has greatly expanded in recent years due to advances in instrumentation, algorithms and software. This volume describes the latest innovations in the field and in the applications of analytical ultracentrifugation in the analysis of macromolecules, macromolecular assemblies, and biopharmaceuticals. - Timely contribution that describes a rapidly changing field - Leading researchers in the field - Broad coverage: instrumentation, basic theory, data analysis, and applications

Das Schweizer Buch
  • Language: un
  • Pages: 856

Das Schweizer Buch

  • Type: Book
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  • Published: 2007
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  • Publisher: Unknown

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Regroupements des familles Pepin
  • Language: fr
  • Pages: 418

Regroupements des familles Pepin

Un dictionnaire généalogique s'addressant à toutes les personnes avec les patronymes Pépin, Pepin ou Pepin/Lachance, descendants de Guillaume (né à St-Laurent de la Barrière, diocèse de Saintonge, France), d'Antoine (né au Havre, en Normandie, France, le 10 avril 1636) ou Robert (né à Grisy, en Normandie, en 1643). Les descendants habitent au Canada et aux États-Unis.

Analysis of Aggregates and Particles in Protein Pharmaceuticals
  • Language: en
  • Pages: 480

Analysis of Aggregates and Particles in Protein Pharmaceuticals

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

Methods of Cancer Diagnosis, Therapy and Prognosis
  • Language: en
  • Pages: 612

Methods of Cancer Diagnosis, Therapy and Prognosis

Cancer is the leading cause of death, in the number of older cancer patients is after cardiovascular diseases, in the expected. Approximately, 77% of all types United States. A total of ? 1,399,790 new of cancers are diagnosed in persons of 55 cancer cases and ? 564,830 deaths were years and older. It was estimated that o- reported in the year 2006 in the country. third of the 559,650 cancer deaths in 2007 Approximately, one in every two men and in the United States were related to ov- one in every three women in the country weight or obesity, physical inactivity, and will have some type of cancer during nutrition, and thus could also be prevented their lifetime. Healthcare costs exceed (Am....

The Commissioners of Patents' Journal
  • Language: en
  • Pages: 1702

The Commissioners of Patents' Journal

  • Type: Book
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  • Published: 1861
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  • Publisher: Unknown

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