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Multi-System Endocrine Disruption
Endocrine disruption is an expanding field due to the numerous chemicals involved and, as evidenced more recently, the variety of homeostatic systems that they can alter throughout life. The gathering of experts from all over the world should help to identify health disorders that are possibly or likely related to exposure to endocrine disrupters. The research needs have been discussed as well as recommendations prioritizing target groups and following the precautionary principle.
Growth Factors
Hormonal Proteins and Peptides: Growth Factors, Volume XII focuses on the chemistry and biology of nerve growth factor (NGF), insulin-like growth factors/somatomedins/multiplication-stimulating activity (IGFs/SMs/MSA), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and skeletal growth factor (SGF). This book discusses the development of growth factors in cell proliferation, differentiation, and malignancy. Organized into eight chapters, this volume starts with an overview of the findings on the structural and biological properties of NGF. This text then discusses the identical amino acid sequences of IFG-I and SM-c and explains as well the similarities in the structure of IFG-II and MSA. Other chapters present a thorough discussion of human PDGF, with emphasis on the link between the PDGF and the simian sarcoma virus gene product. This book discusses as well the mechanism of action of the pituitary and brain FGF. The final chapter deals with the discovery, isolation, and characterization of the biological activities of epidermal growth factor (EGF). This book is a valuable resource for biochemists, endocrinologists, and physicians.
Structure and Function of Peptidergic and Aminergic Neurons
Chemical markers have brought important new dimensions to the studies of the brain. As a result of this development, the chemical anatomy of the neurons system is being explored in great detail. This new functional neuroanatomy has demonstrated new organizations of perikaryal groupings of neurons and pathways from these cells which often follow unexpected courses. The field of chemical identification has recently been improved by methods reported in this volume, e.g. serotonin locatization and direct labelling of cholinergic neurons. The new techniques provide a ''new pair of glasses'' for everyone working in this field. This volume will be of great interest for researchers in neuropharmacology, neuroanatomy, immunochemistry, neuroendocrinology, neuroscience and cell biology.
Gonadotropic Hormones
Hormonal Proteins and Peptides, Volume XI: Gonadotropic Hormones deals with gonad stimulating hormones that cause precocious sexual maturity. This book begins by reviewing the relationship of the chemical structure to the biological activity of gonadotropins and chorionic hormones, followed by a brief presentation on the in vitro bioassay methods. A comprehensive discussion on some aspects of the molecular mechanism of gonadotropin action is also provided. This publication concludes with an analysis of the immunobiology of gonadotropins. This book is intended for endocirnologists, but is also useful for medical practitioners and researchers concerned with gonadotropic hormones.
Wildlife Review
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The Human Testis
This volume describes the proceedings of the Workshop Conference on The Human Testis which was held at Positano, Italy, April 23-25, 1970. The format of the book has been arranged according to topics discussed during the Conference. Each chapter includes individual contributions followed by discussion. Thus, this volume provides a current critical evaluation of the subjects discussed. The Editors assume responsibility for any shortcomings and wish to thank all par~ ticipants for their unprecedented cooperation in making this publi cation possible. The Editors are indebted to Miss Barbara Martin for her able secretarial and administrative assistance and to Mrs. Griff T. Ross who supervised th...
B-Endorphin
Hormonal Proteins and Peptides: ß-Endorphin, Volume X focuses on the chemistry, biology, and clinical investigations of opioid peptides. This book discusses the chemical approach in isolating a chemical entity from its natural source and investigates its biological activity after it has been determined to be a pure substance. Organized into nine chapters, this volume starts with an overview of the structure–activity relationship of ß-endorphin (ß-EP) by synthetic approach. This text then explores the proteinases involved in the generation of opioid peptides, including ß-EP from ß-lipotropin (ß-LPH). Other chapters review the biosynthesis of ß-EP and consider in detail the opiate receptor. This book discusses as well the anatomy of ß-EP-containing structures in pituitary and brain. The final chapter presents a discussion on the historical aspects of opiate–peptide discoveries, particularly in the field of narcotic antagonists. This book is a valuable resource for chemists, biologists, endocrinologists, physicians, and neurobiologists.
Mobilizing Mutations
With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.
Human Prolactin
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