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From Switzerland
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Small Business Sourcebook
A guide to the information services and sources provided to 100 types of small business by associations, consultants, educational programs, franchisers, government agencies, reference works, statisticians, suppliers, trade shows, and venture capital firms.
Publishers' Directory
Provides detailed information on more than 20,000 U.S. and Canadian publishers, including nearly 1,000 distributors, wholesalers and jobbers, as well as small independent presses. The latest edition adds approximately 500 new entries with increased Canadian listings and Web site and e-mail addresses.
Publishers Directory
Gale's Publishers Directory is your one-stop resource for exhaustive coverage of approximately 30,000 U.S. and Canadian publishers, distributors and wholesalers. Organizations profiled in the Publishers Directory represent a broad spectrum of interests, including major publishing companies; small presses (in the traditional, literary sense); groups promoting special interests from ethnic heritage to alternative medical treatments; museums and societies in the arts, science, technology, history, and genealogy; divisions within universities that issues special publications in such fields as business, literature and climate studies; religious institutions; corporations that produce important publications related to their areas of specialization; government agencies; and electronic and database publishers.
Cross-Cultural Survey Methods
Table of contents
Heat Shock Proteins in Cancer
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
