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The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism
In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up-to-date, state-of-the-art review of current paraoxonase research. The book details a unique and novel enzyme whose physiological/pathological function(s) are just starting to be revealed.
Paraoxonase (PON1) in Health and Disease
The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e. , not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different indivi...
Toxic Exposures
The increase in environmentally induced diseases and the loosening of regulation and safety measures have inspired a massive challenge to established ways of looking at health and the environment. Communities with disease clusters, women facing a growing breast cancer incidence rate, and people of color concerned about the asthma epidemic have become critical of biomedical models that emphasize the role of genetic makeup and individual lifestyle practices. Likewise, scientists have lost patience with their colleagues' and government's failure to adequately address environmental health issues and to safeguard research from corporate manipulation. Focusing specifically on breast cancer, asthma...
The HDL Handbook
The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol. - Provides bench-to-bedside coverage of HDL with thorough coverage of basic science, genetics, epidemiology, and treatment - Presents a complete update with six new chapters on the latest advances in HDL cholesterol research with international perspective - New chapters on proteomics, clinical impact of LCAT in HDL metabolism, and an in-depth discussion of potential targets to modify HDL provide a translational reference for clinicians
Paraoxonases in Inflammation, Infection, and Toxicology
*** This series does not include back cover copy. ***
Atherosclerosis XIII
These proceedings not only summarized the scientific and technological achievements in atherosclerosis research during the 20th century but also include the latest topics for future progress and development in this new millennium, highlighting the recent advances in vascular biology, angiogenesis and atherogenesis, pathogenesis of metabolic syndrome. The articles also encompass vast range of clinical and basic research field of atherosclerosis, including epidemiology, lipoprotein metabolism, pharmacology, clinical trials, nutrition, pathogenesis, diagnosis and prevention as well as its treatment.
Paraoxonase (PON1) in Health and Disease
The journey to find genes responsible for determining sensitivity or resistance to specific insecticides led to the paraoxonase (PON1) gene on human chromosome 7. This gene encodes a 355 amino acid protein that is localized on the high density lipoprotein (HDL) particles in plasma. Characterization of this gene revealed that different individuals expressed both different forms of this enzyme with amino acid substitutions at positions 55 and 192 as well as different levels of this protein. Additional studies showed that mutations in the regulatory region of the PON1 gene contributed to the very different levels of plasma PON1 among individuals. It turned out that both the level of the enzyme ...
