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New Non-opioid Analgesics: Understanding Molecular Mechanisms on the Basis of Patch-clamp and chemical Studies
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation o...
Focus on Chronic Pain: Neuropathological Mechanism, Clinical Diagnosis and Treatment
Pain is an unpleasant sensory and emotional experience and the most frequent causes for patients to seek medical care. Persistent chronic pain affects millions of people worldwide, causing low quality of health and emotional status, as well as posing a significant social and economic burden. Chronic pain is the long-standing pain that are classified as different types, including chronic primary pain and secondary pain types caused by various diseases. The complexity of cause and symptom in chronic pain is associated with changes in different levels of nervous system, from molecular interaction, synaptic connection, cellular response, and neural circuits. The development of new treatments to manage chronic pain shall base on the better standing of the neuropathological mechanism underlying the symptom, the exploration on the methods of a better diagnosis, and the communication of clinical application standards and results.
Cold Weather Concreting
Concreting in cold weather requires special knowledge and skills to ensure accelerated hardening and high quality in plain- and reinforced-concrete structures. Cold Weather Concreting familiarizes concrete specialists with the characteristic features of concrete in cold weather, including the effects of frost, methods for hardening in subzero temperatures, and other challenges in cold-weather concreting. Both practical techniques and their underlying theories are covered. The book presents many methods for the thermal treatment of concrete by means of electric current--information previously available only in the Russian literature. It presents unique data in the form of diagrams, drawings, and tables, including a chart of the phase state of concretes of different strengths in the process of freezing at different temperatures, the variation of concrete strains in freezing and thawing, and a diagram of electric fields in concrete when electrodes are placed in front of stirrups.
Physiology and Maintenance - Volume I
Physiology and Maintenance is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on Physiology and Maintenance with contributions from distinguished experts in the field, discusses the functions of our body and their regulations which are some of the most fascinating areas of science. The content of the theme is organized with state-of-the-art presentations covering the following aspects of the subject: General Physiology; Enzymes: The Biological Catalysts of Life; Nutrition and Digestion; Renal Excretion; Endocrinology; Respiration; Blood Circulation: Its Dynamics And Physiological Control; Locomotion in Sedentary Societies; Neurophysiology; Plant Physiology and Environment : A Synopsis, which are then expanded into multiple subtopics, each as a chapter. These five volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
MEDICAL AND HEALTH SCIENCES - Volume I
Medical and Health Sciences is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. These volume set contains several chapters, each of size 5000-30000 words, with perspectives, applications and extensive illustrations. It carries state-of-the-art knowledge in the fields of Medical and Health Sciences and is aimed, by virtue of the several applications, at the following five major target audiences: University and College Students, Educators, Professional Practitioners, Research Personnel and Policy Analysts, Managers, and Decision Makers and NGOs.
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Dynamic Knowledge Representation in Scientific Domains
The main approach to understanding and creating knowledge engineering concepts is static knowledge. Currently, there is a need to approach knowledge through a dynamic lens and address changing relations on an elaborated syntactic and semantic basis. Dynamic Knowledge Representation in Scientific Domains provides emerging research on the internal and external changes in knowledge within various subject areas and their visual representations. While highlighting topics such as behavior diagrams, distribution analysis, and qualitative modeling, this publication explores the structural development and assessment of knowledge models. This book is an important resource for academicians, researchers, students, and practitioners seeking current research on information visualization in order to foster research and collaboration.
