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Antiviral Nucleosides
• Up-to-date review on the chemistry and biology of nucleosides • Modern synthetic methodology • Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.
A Global Perspective of Young Adolescents’ Peer Aggression and Well-being
Reporting on the findings from a study of young people across 11 different world locations (Australia, Mainland China, Greece, India, Indonesia, Italy, Korea, The Philippines, Poland, Spain, and Taiwan), A Global Perspective of Young Adolescents’ Peer Aggression and Well-being looks beyond bullying to assess the harm to mental health and well-being of young people experiencing peer aggression in all its forms. The first book in a global movement that recommends a new dialogue on peer aggression, this book delves into the poorly understood nexus of peer aggression and bullying through the use of statistical data from questionnaires, as well as the students’ own words and illustrations. By considering data from multiple countries, it addresses critical questions about cultural variation in aggression and associated well-being. Addressing the issue that there is a growing focus on other forms of aggression other than bullying, A Global Perspective of Young Adolescents’ Peer Aggression and Well-being will offer invaluable insight for practicing teachers and school counsellors, as well as any researchers with an interest in the health and well-being of young adolescents.
Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine
In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available. This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.
Protocols for Oligonucleotides and Analogs
When first conceived, not only was the aim of Protocols for Oligo nucleotides and Analogs to provide wide coverage of the ohgonuc- otide chemistry field for readers who are well versed within the field, but also to give investigators just entering into the field a new perspective. The very first book on this topic was edited and published by Michael Gait in 1984, in whose laboratory I encountered the newer aspects of oligonucleotide chemistry. Since then, oligonucleotide research has developed to such an extent that its uses extend far beyond basic studies, and now find wide application throughout clinical science as well. Until recently, the major application of oligonucleotides has been in...
Environmental Design Sourcebook
How do we design in a climate emergency? A new social and ecological prerogative demands appropriate material choices, a re-invention of construction and evolving building programmes that look at lifecycle, embodied energy and energy use. Highly illustrated with practical information and simple explanations for design ideas, this book is the perfect introduction to sustainable design for architecture students. It presents key concepts in relation to the embodied energy of construction, material properties and environmental performance of buildings in an accessible way. In explaining the principles and technologies by which we heat, cool, moderate and mitigate, it demystifies environmental de...
DNA Conjugates and Sensors
Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and applic...
New Perspective in Atrial Fibrillation
In spite of the large volume of associated research, the pathophysiological mechanisms involved in atrial fibrillation (AF) onset and recurrence remain uncertain. This may explain why the performances of thromboembolic and bleeding prediction scores in AF patients are limited. In the past few years, the concept of atrial cardiopathy has emerged as a promising lead to connect AF to stroke, heart failure, and inflammatory processes: indeed, all of the mechanisms associated with atrial remodeling and the development of atrial cardiopathy are also likely to promote the development of AF. This recent concept of atrial cardiopathy suggests that the real trigger of stroke may be an abnormal atrial ...
Introduction to Architectural Technology Third Edition
Understanding the relationship between design and technology is critical to the understanding of architecture. This book clearly explains the core aspects of architectural technology: structural physics, structural elements and forms, heating, lighting, environmental control and computer modelling. The third edition includes six new case studies, more on structural types, new information on construction detailing, passive building principles and designing for different climatic conditions. This essential introduction to architecture will help students to integrate their design thinking with the appropriate structural and environmental solutions.
The Architecture of Natural Cooling
Overheating in buildings is commonplace. This book describes how we can keep cool without conventional air-conditioning: improving comfort and productivity while reducing energy costs and carbon emissions. It provides architects, engineers and policy makers with a ‘how-to’ guide to the application of natural cooling in new and existing buildings. It demonstrates, through reference to numerous examples, that natural cooling is viable in most climates around the world. This completely revised and expanded second edition includes: An overview of natural cooling past and present. Guidance on the principles and strategies that can be adopted. A review of the applicability of different strategies. Explanation of simplified tools for performance assessment. A review of components and controls. A detailed evaluation of case studies from the USA, Europe, India and China. This book is not just for the technical specialist, as it also provides a general grounding in how to avoid or minimise air-conditioning. Importantly, it demonstrates that understanding our environment, rather than fighting it, will help us to live sustainably in our rapidly warming world.
Act Cool
*Named a Rainbow Book List Title and one of Bank Street Children's Best Books of the Year* A trans teen walks the fine line between doing whatever it takes for his acting dream and staying true to himself in this moving, thought-provoking YA novel from the acclaimed author of Stay Gold. Aspiring actor August Greene just landed a coveted spot at the prestigious School of Performing Arts in New York. There’s only one problem: His conservative parents won’t accept that he’s transgender. And to stay with his aunt in the city, August must promise them he won’t transition. August is convinced he can play the part his parents want while acting cool and confident in the company of his talented new friends. But who is August when the lights go down? And where will he turn when the roles start hitting a little too close to home?
