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Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology
This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heav...
Toll-Like Receptor Family Members and Their Ligands
On occasion, the innate immune system is referred to as the "primitive" immune system. Perhaps this has dissuaded immu nologists from analyzing it as energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisti cated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due. Any immune system has two cardinal functions. It must destroy a broad range of pathogens, and it must spare the host. The adaptive immune system has applied a modular solution to these problems. Each cell of the adaptive immune system is prescreened to eliminate those that would produce untoward interactions with self; each cell is pre-programmed to recognize a foreign epitope that the host might one day encounter. Hence, the duties of each individual lymphocyte are quite circumscribed.
Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology
This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heav...
Path to Nobel
Genius is often associated with high creativity, originality, and insight. Curiosity can be seen as a precursor to discovery, innovation, and creativity. The ability to think and work independently or in teams is also essential to achieve. Creativity and teamwork can be cultivated and trained. So we attempted to cultivate these qualities in students through this book.
Anthony Cerami
Since the turn of the new millennium, ‘translational research’, the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe. Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline’s most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in ...
Comprehensive Textbook of Psychotherapy
Preceded by Comprehensive textbook of psychotherapy: theory, and practice / edited by Bruce Bongar, Larry E. Beutler. 1995.
Am I Crazy, Or Is It My Shrink?
With over 400 types of psychotherapy available, ranging from the highly effective to the highly questionable to the downright fraudulent, the task of choosing a therapist can be daunting. Now, Am I Crazy Or Is My Shrink? gives you all the information you need to get the most effective help and to know when your therapy is working--or when it's time for a change. Drawing on years of practical experience and the most up-to-date research, the authors give you expert guidance on all the issues you should consider, whether you're seeking therapy or uncertain about the therapy you're receiving: What questions should I ask my therapist about a recommended treatment? What personal qualities and prof...
Psychology of Terrorism
During the past decade, we have witnessed a dramatic transformation in the nature and uses of terrorism. In the 70s, it was often repeated that terrorists "want a lot of people watching, not a lot of people dead"; today, it is more accurate to say that terrorists want a lot of people dead, and even more people crippled by fear and grief. A major strategic intent of modern terrorists is to use larger scale physical attacks to cause stress in the general population. These changes in terrorist strategy have made it clear that we need better psychological and social responses to terrorism and man-made disasters. The psychological science needed to provide proper and effective treatment for victi...
Biologics for the Treatment of Rheumatoid Arthritis
This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information for all rheumatologists and health care professionals treating patients with rheumatoid arthritis.
