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Clinical Trials in the Neurosciences
A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard...
Uncommon Causes of Stroke
An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.
The Dao of Healing
The last 50 years have seen the popularity of Chinese medicine grow exponentially. In China, Korea, Japan and Singapore, Chinese medicine has been incorporated into their healthcare systems to varying degrees. In the West, it is no longer uncommon for patients to consult Chinese medicine doctors, many of whom are non-Chinese. However, among Christians in many parts of the developed world, Chinese medicine is still viewed with suspicion and negativity. Are these fears justified? How can we better understand the roots and practices of Chinese medicine? The Dao of Healing takes us on an in-depth exploration of the histories and philosophies that have shaped both Western biomedicine and Chinese medicine in order that we might make informed judgements about them. If our call is to “love our neighbours”, we need to be able to dialogue with them on the basis of mutual respect and understanding. Let this book be the catalyst for meaningful and productive conversations across the divide.
Handbook of Cerebrovascular Diseases
This volume reviews developments in the diagnosis and management of stroke - discussing the clinical features of stroke, new diagnostic techniques, stroke preventive measures, acute treatment of stroke, sequelae of stroke, and post-stroke rehabilitation.;Written by nearly 50 renowned experts in the field, the Handbook of Cerebrovascular Diseases: explores medical and surgical options to treat transient ischemic attacks as well as the care of patients with acute or progressing ischemic stroke; presents approaches to the management of subarachnoid and intracerebral haemorrhage; considers new methods of treatment such as interventional neuroradiology and thrombolytic therapy; describes approaches to the evaluation and management of heart disease in patients with stroke; analyzes unusual causes of stroke, including stroke in pregnant patients, children and young adults; and examines post-stroke cognitive deficits, psychiatric disorders, and rehabilitation.;Heavily referenced with more than 2600 bibliographic citations, the Handbook of Cerebrovascular Diseases is intended for neurologists, stroke specialists, cardiologists, psychiatrists, and internists.
New Techniques for Identifying the Neural Substrates of Language
This issue includes studies demonstrating how advanced imaging techniques and new methods of recording brain function can reveal areas of the brain that are essential for specific language processes. The first two papers report use of arterial spin labelling (ASL) perfusion MRI to identify areas of poor blood flow (hypoperfusion) that have impaired neural function. The first paper describes a group study that demonstrates that severity of language impairment in aphasic patients is more strongly correlated with extent of hypoperfused tissue than with extent of infarct. The second paper is a detailed single case study of a patient with reading impairment. While conventional MRI in this patient...
Primer on Cerebrovascular Diseases
Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. Presents topics in a comprehensive and accessible format Written by international authorities on cerebral vasculature Provides practical applications for researchers
