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By the mid-1950s, a linear accelerator suitable for treating deep-seated tumors was built in the Stanford Microwave Laboratory and installed at Stanford Hospital. It served as a prototype for commercial units that were built later. Since that time, medical linear accelerators gained in popularity as major radiation therapy devices, but few basic training materials on their operation had been produced for use by medical professionals. C.J. Karzmark, a radiological physicist at Stanford University, was involved with medical linacs since their development, and he agreed to collaborate with Robert Morton of the Center for Devices and Radiological Health (formerly the Bureau of Radiological Health), U.S. Food and Drug Administration, in writing the first edition of this primer.
Organized to serve as a ready reference, this book covers the design & principles of operation of microwave electron linear accelerators for the radiation treatment of cancer. Designed for use by persons without extensive knowledge & experience of accelerator technology, the book assumes a knowledge of elementary physics & mathematics & places its emphasis on how accelerators actually function & how they are used in cancer treatment. Coverage includes the history of development & application, general theory of acceleration, accelerator systems, radiation beam systems & associated equipment, performance characteristics, testing & use. The major modules of a representative medical accelerator are described, including principles of operation & how these models function collectively to produce electron & X-ray beams for radiotherapy.
Dr. Khan's classic textbook on radiation oncology physics is now in its thoroughly revised and updated Fourth Edition. It provides the entire radiation therapy team—radiation oncologists, medical physicists, dosimetrists, and radiation therapists—with a thorough understanding of the physics and practical clinical applications of advanced radiation therapy technologies, including 3D-CRT, stereotactic radiotherapy, HDR, IMRT, IGRT, and proton beam therapy. These technologies are discussed along with the physical concepts underlying treatment planning, treatment delivery, and dosimetry. This Fourth Edition includes brand-new chapters on image-guided radiation therapy (IGRT) and proton beam therapy. Other chapters have been revised to incorporate the most recent developments in the field. This edition also features more than 100 full-color illustrations throughout. A companion Website will offer the fully searchable text and an image bank.
An in-depth introduction to radiotherapy physics emphasizing the clinical aspects of the field. This second edition gradually and sequentially develops each of its topics in clear and concise language. It includes important mathematical analyses, yet is written so that these sections can be skipped, if desired, without compromising understanding. The book consists of seven parts covering basic physics (Parts I-II), equipment for radiotherapy (Part III), radiation dosimetry (Parts IV-V), radiation treatment planning (Part VI), and radiation safety and shielding (Part VII). An invaluable text for radiation oncologists, radiation therapists, and clinical physicists.
The history of the development of cancer therapy has been marked by a recurring pattern, one of initially exciting and encouraging results as new methods were introduced, followed by dismaying failures. The extremity of the disease and its high mortality have dictated that each means of damaging tumor cells would be rapidly explored and exploited as a mode of therapy, long before the correspond ing theory and technique were completely understood and perfected. Thus radiation was used as an antitumor agent almost immediately following recogni tion of its cytodestructive capability. Equally constant, following the rapid utilization of new therapeutic methods, has been a period of significant t...
First multi-year cumulation covers six years: 1965-70.