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Animal Models of Human Birth Defects
This book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects.
Computer Performance Engineering
This book constitutes the refereed proceedings of the 16th European Workshop on Computer Performance Engineering, EPEW 2019, held in Milan, Italy, in November 2019. The 10 papers presented in this volume together with one invited talk were carefully reviewed and selected from 13 submissions. The papers presented at the workshop reflect the diversity of modern performance engineering, with topics ranging from modeling and analysis of network/control protocols and high performance/BigData information systems, analysis of scheduling, blockchain technology, analytical modeling and simulation of computer/network systems.
Universal Design
A much-needed reference to the latest thinking in universal design Universal Design: Creating Inclusive Environments offers a comprehensive survey of best practices and innovative solutions in universal design. Written by top thinkers at the Center for Inclusive Design and Environmental Access (IDeA), it demonstrates the difference between universal design and accessibility and identifies its relationship to sustainable design and active living. Hundreds of examples from all areas of design illustrate the practical application of this growing field. Complete, in-depth coverage includes: • The evolution of universal design, from its roots in the disability rights movement to present-day tre...
Infection and Inflammation
The last two decades have shown that the local microenvironment plays a pivotal role in cancer progression. Cancer is not the result of mutation events in single cells, but of a complex interplay of tumor cells, inflammatory cells, stem cells, growth factors, cytokines, chemokines and DNA-damaging agents. This book provides an up-to-date overview of how infections and chronic inflammatory conditions can give rise to the onset of a malignant phenotype, a theory that was originally postulated by Rudolf Virchow as early as 1863. Internationally recognized experts discuss novel aspects such as the role of stem cells and the occurrence of aneuploidy in carcinogenesis. Several examples of pathogen...
Clinical Virology
Informs scientists and health care professionals about all the medically relevant aspects of this rapidly evolving field. • Covers novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention. • Addresses infections and syndromes related to particular organ systems, as well as the fundamentals of modern medical virology. • Includes crucial information on immune responses and vaccinology, diagnostics, antivirals, and the nascent field of gene therapy. • Provides agent-specific chapters that detail the virology, epidemiology, pathogenesis, clinical manifestations, and prevention and treatment of important viral pathogens.
