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Cardiac Cell Biology
Cardiac cell biology has come of age. Recognition of activated or modified signaling molecules by specific antibodies, new selective inhibitors, and fluorescent fusion tags are but a few of the tools used to dissect signaling pathways and cross-talk mechanisms that may eventually allow rational drug design. Understanding the regulation of cardiac hypertrophy in all its complexity remains a fundamental goal of cardiac research. Since the advancement of adenovirally mediated gene transfer, transfection efficiency is no longer a limiting factor in the study of cardiomyocytes. A limiting factor in considering cell transplantion as a strategy to repair the damaged heart is cell availability at the right time. Cardiac gap junctions, intercellular communication channels that allow electrical and metabolic coupling and play an important role in arrhythmogenesis are now understood to be exquisite sensors of cardiac change. The reports in this volume incLude elegant studies that made use of cutting edge technological advances and many specialized reagents to address these issues.
Myocardial Ischemia
Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid expo nential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcrip tional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ische...
Perspectives on Pantomime
Pantomime is a unique form of communication, which we improvise “on the fly” to transmit information when unable to use language, for example during intercultural contacts or when the use of language is blocked or constrained, as in the case of some medical conditions or the game of charades. Pantomimic communication has been investigated from a number of perspectives, including neuropsychological, developmental and gesture research. Recently, pantomime has come under the attention of evolutionary linguistics as a strong candidate for a precursor of verbal communication. The volume Perspectives on pantomime: evolution, development, interaction brings together authors who are at the forefront of these studies, which challenge the notion that pantomime is merely a fallback mode of expression. This multidisciplinary journey traverses language evolution, cognitive science, cognitive semiotics, sign language linguistics, psychology and gesture studies to unveil the profound role that pantomime plays in human communication.
A History of Pantomime
Each Christmas entire families in the UK troop off to see, what one could almost say is 'the obligatory'. annual entertainment, known as Pantomime. It is a traditional, seasonal way of life for the British envied the world over, and one which only the British seem to understand! Pantomime serves both to entertain and to introduce each new generation to the joys of theatre in the most unique of ways, for this is not a type of theatre one merely watches, but one in which the audience participate often in the most seemingly boisterous and bizarre of ways. The whole experience is steeped in tradition, traditions which only the British seem to understand, which is probably why we are proud to cal...
