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Recent Advances in Computational and Experimental Mechanics, Vol II
This book (Vol. II) presents select proceedings of the first Online International Conference on Recent Advances in Computational and Experimental Mechanics (ICRACEM 2020) and focuses on theoretical, computational and experimental aspects of solid and fluid mechanics. Various topics covered are computational modelling of extreme events; mechanical modelling of robots; mechanics and design of cellular materials; mechanics of soft materials; mechanics of thin-film and multi-layer structures; meshfree and particle based formulations in continuum mechanics; multi-scale computations in solid mechanics, and materials; multiscale mechanics of brittle and ductile materials; topology and shape optimiz...
Pain Therapeutics
This book presents a contemporary review of the field of pain therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets and pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific developments in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally, the book covers the discovery and development stories of two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product.
The Medicinal Chemist's Guide to Solving ADMET Challenges
Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
A Multidisciplinary Approach to Managing Swallowing Dysfunction in Older People
A Multidisciplinary Approach to Managing Swallowing Dysfunction in Older People provides comprehensive coverage on oropharyngeal dysphagia (OD), focusing on older patient phenotypes. The book provides the knowledge needed for translational researchers and professionals to aid in the detection, diagnosis, treatment and management of OD, ultimately improving patient quality of life. OD has been recently considered a geriatric syndrome because of its high prevalence, the increase of life-expectancy and the need to be managed by a multidisciplinary approach. This reference takes a novel approach to OD, covering all aspects as a geriatric syndrome, examining a complicated and multi-level topic in...
Myeloproliferative Neoplasms: Biology and Treatment
Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) - including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PM) - are clonal stem cell disorders characterized by acquired activating mutations which result in an excessive production of red blood cells, platelets, and neutrophils. Recent advances in the understanding of the molecular biology and genomics of MPNs have led to the development of novel targeted treatment approaches; however, the high rate of life-threatening vascular events and the high risk of disease progression with myelofibrotic and leukemic transformation continue to present challenges in the management of MPNs. Thereby, there remains a need for novel treatment strategies. Recently, research has revealed a role for clonal hematopoiesis, driver mutations and inflammation in thrombosis risk, which may provide a basis for novel thrombosis-prevention strategies.
Sedation and Analgesia for the Pediatric Intensivist
This book provides a comprehensive overview on sedation and analgesia for the pediatric intensivist. Divided into two primary sections, the text presents a framework on how to care for patients who need sedation, analgesia, and neuromuscular blockade inside the pediatric ICU (PICU), and how to manage procedural sedation in an outpatient setting. The first section focuses on sedation and analgesia for the critically ill child, with an emphasis on analgesics, sedatives, neuromuscular blockade, tolerance and withdrawal, and the PICU environment. The second section centers around procedural sedation, detailing patient selection, pre-sedation assessment, how to choose a sedation regimen, available agents, and nursing considerations. Written by experts in the field, Sedation and Analgesia for the Pediatric Intensivist: A Clinical Guide is a valuable resource for the pediatric intensivist in caring for their patients both inside and outside the PICU.
Wintrobe's Clinical Hematology
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Social Exclusion
From ostracism on the playground to romantic rejection, bullying at work, and social disregard for the aged, individuals are at constant risk of experiencing instances of social exclusion, including ostracism, rejection, dehumanization, and discrimination. These phenomena have a powerful impact as testified by their immediate influence on people’s thoughts, emotions, and behaviors. Social Exclusion: Psychological Approaches to Understanding and Reducing Its Impact investigates different psychological approaches, across multiple psychological subdisciplines, to understanding the causes and consequences of social exclusion and possible ways to reduce or buffer against its negative effects. T...
Update on the Immune Mechanisms Against Respiratory Pathogens
Respiratory infections are leading causes of mortality and morbidity, with Tuberculosis and lower respiratory tract infections (LRTI) culminating in almost 5 million deaths per year. Respiratory tract infections pose a continuous threat to humans due to their easy dissemination via aerial transmission. Children under the age of five living in developing countries are the most susceptible hosts to a plethora of bacteria and viruses including Mycobacterium tuberculosis, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Klebsiella pneumoniae, Bordetella pertussis, Pseudomonas aeruginosa, Mycoplasma pneumoniae, Influenza virus, Respiratory syncytial virus and metapneumovir...
