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Dendrites
Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and ...
The Neuropilins: Role and Function in Health and Disease
This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.
The Dynamic Neuron
A comprehensive review of current research on synaptic plasticity. The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.
Imaging of the Shoulder
This volume covers the broad spectrum of imaging methods and abnormalities of relevance in the diagnostic workup of the shoulder. In the first part of the book, individual chapters are devoted to radiography, arthrography, computed tomography and CT arthrography, magnetic resonance imaging and MR arthrography, ultrasound and interventional procedures. Controversies regarding the use of the different imaging techniques are explained and discussed. The second part of the book then documents the application of these techniques to each of the clinical problems and diseases encountered in the shoulder. The authors are all experts in their field and include rising stars of musculoskeletal radiology. This well-illustrated book will assist the general and the musculoskeletal radiologist in planning, guiding and interpreting imaging studies. For the clinician it puts into perspective the role of the different imaging methods.
MRI of the Musculoskeletal System
MRI of the Musculoskeletal System, Sixth Edition, comprehensively presents all aspects of MR musculoskeletal imaging, including basic principles of interpretation, physics, and terminology before moving through a systematic presentation of disease states in each anatomic region of the body. Its well-deserved reputation can be attributed to its clarity, simplicity, and comprehensiveness. The Sixth Edition features many updates, including: New pulse sequences and artifacts in the basics chapters Over 3,000 high-quality images including new anatomy drawings and images FREE access to a companion web site featuring full text as well as an interactive anatomy quiz with matching labels of over 300 images.
