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First multi-year cumulation covers six years: 1965-70.
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The present volume contains 22 articles written by leading experts in natural product chemistry on biologically active natural produc...
Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.
Writing as Material Practice grapples with the issue of writing as a form of material culture in its ancient and more recent manifestations, and in the contexts of production and consumption. Fifteen case studies explore the artefactual nature of writing — the ways in which materials, techniques, colour, scale, orientation and visibility inform the creation of inscribed objects and spaces, as well as structure subsequent engagement, perception and meaning making. Covering a temporal span of some 5000 years, from c.3200 BCE to the present day, and ranging in spatial context from the Americas to the Near East, the chapters in this volume bring a variety of perspectives which contribute to both specific and broader questions of writing materialities. The authors also aim to place past graphical systems in their social contexts so they can be understood in relation to the people who created and attributed meaning to writing and associated symbolic modes through a diverse array of individual and wider social practices.
Cephalopod Culture is the first compilation of research on the culture of cephalopods. It describes experiences of culturing different groups of cephalopods: nautiluses, sepioids (Sepia officinalis, Sepia pharaonis, Sepiella inermis, Sepiella japonica Euprymna hyllebergi, Euprymna tasmanica), squids (Loligo vulgaris, Doryteuthis opalescens, Sepioteuthis lessoniana) and octopods (Amphioctopus aegina, Enteroctopus megalocyathus, Octopus maya, Octopus mimus, Octopus minor, Octopus vulgaris, Robsonella fontaniana). It also includes the main conclusions which have been drawn from the research and the future challenges in this field. This makes this book not only an ideal introduction to cephalopod culture, but also a valuable resource for those already involved in this topic.