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Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain.
Provides a comprehensive overview of key methods for treating water tainted by cyanobacteria and cyanotoxins Toxigenic cyanobacteria are one of the main health risks associated with water resources. Consequently, the analysis, control, and removal of cyanobacteria and cyanotoxins from water supplies is a high priority research area. This book presents a comprehensive review of the state-of-the-art research on water treatment methods for the removal of cyanobacteria, taste and odor compounds, and cyanotoxins. Starting with an introduction to the subject, Water Treatment for Purification from Cyanobacteria and Cyanotoxins offers chapters on cyanotoxins and human health, conventional physical-c...
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The A...
Contains sample standardized Nursing Care Plans in appendix.
This book addresses the impact of migration on the formation and transformation of identity and its continuous negotiations. Its ground is the understanding of identity as a complex social phenomenon resulting from constant negotiations between personal conditions, social relationships, and institutional frameworks. Migrations, understood as dynamic processes that do not end when landing in the host country, offer the best conditions to analyze the construction and transformation of social identities in the postcolonial and globalized societies. Searching for novel epistemologies and methodologies, the research questions here addressed are how identity is negotiated in migration processes, and how these negotiations work in contemporary multiethnic Europe. This edited volume brings to the field a novel convergence of theoretical and empirical approaches by gathering together scholars from different countries of Europe and the Mediterranean area, from different disciplines and backgrounds, challenging the traditional discipline division.
The papers in this volume draw attention to both new and recent information on the mechanisms employed by infectious pathogens to underpin their survival in the immunocompetent host and to facilitate their transmission between hosts.
This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.
Under the auspices of the 12th International Symposium on Special Aspects in Radiotherapy 2008 in Berlin, acknowledged experts presented their perspectives on small and non-small cell lung cancer, reflecting the latest standards and engaging in controversies in the diagnosis and treatment of this disease.In the first part of this volume, aspects of the diagnostic workup are highlighted from the histopathologist's point of view, followed by presentations concerning the value of PET-CT and whole-body MRI in the staging of lung cancer. The use and current methods in bronchoscopy, endoscopic ultrasound, video-endoscopy and mediastinoscopy are discussed in detail. The second section presents surg...
This comprehensive publication on biological actions of hydrazines includes all the available published material and chronological descriptions of the literature. The uniformly applied principle of evaluations separates each hydrazine chemical and divides according to species. This monograph presents data on carcinogenic activity of hydrazines in animals.