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Current Challenges in Cardiovascular Molecular Diagnostics
The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery of additional genes associated with human cardiac diseases, the analysis of large dataset of genetic information uncovered a much more complex and variegated landscape, which often departs from the comfort zone of the monogenic Mendelian diseases image that clinical molecular geneticists have been well acquainted with for many decades. It is now clear that, in addition to highly penetrant genetic variants, which in isolation are able to recapitulate the full clinical presen...
Pigeons
They have been worshipped as fertility goddesses and revered as symbols of peace. Domesticated since the dawn of humankind, they have been crucial to wartime communications for every major historical superpower from ancient Egypt to the United States and are credited with saving thousands of lives. One delivered the results of the first Olympics in 776 BC and another brought the news of Napoleon's defeat at Waterloo more than 2500 years later. Charles Darwin relied heavily upon them to help formulate and support his theory of evolution. Yet today the pigeon is reviled as a rat with wings. How did we come to misunderstand one of humanity's most steadfast companions?In Pigeons, Andrew D. Blechman travels across the United States and Europe in a quest to chronicle the bird's transformation from beloved friend to feathered outlaw.
Long QT Syndrome, An Issue of Cardiac Electrophysiology Clinics
Long QT syndrome is a heart rhythm disorder that can cause fast, chaotic heartbeats. In some cases, long QT syndrome can cause sudden death. Long QT syndrome may result from a genetic mutation or be caused by certain medications and medical conditions. The condition is treatable with medication, surgery, or an implantable device. Because it may have serious consequences, it's important for electrophysiologists to know about long QT syndrome.
Heart Rate and Rhythm
Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
Cardiovascular Therapeutics
Manage cardiovascular problems more effectively with the most comprehensive resource available! A trusted companion to Braunwald's Heart Disease, Cardiovascular Therapeutics, 4th Edition addresses pharmacological, interventional, and surgical management approaches for each type of cardiovascular disease. This practical and clinically focused cardiology reference offers a balanced, complete approach to all of the usual and unusual areas of cardiovascular disease and specific therapies in one concise volume, equipping you to make the best choices for every patient. Understand current approaches to treating and managing cardiovascular patients for long-term health, for complex problems, and for...
Electrophysiological Disorders of the Heart E-Book
The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient probl...
Muscle 2-Volume Set
Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.
Artificial Intelligence in Medicine
This book constitutes the refereed proceedings of the 15th Conference on Artificial Intelligence in Medicine, AIME 2015, held in Pavia, Italy, in June 2015. The 19 revised full and 24 short papers presented were carefully reviewed and selected from 99 submissions. The papers are organized in the following topical sections: process mining and phenotyping; data mining and machine learning; temporal data mining; uncertainty and Bayesian networks; text mining; prediction in clinical practice; and knowledge representation and guidelines.
