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We Created Chávez
Since being elected president in 1998, Hugo Chávez has become the face of contemporary Venezuela and, more broadly, anticapitalist revolution. George Ciccariello-Maher contends that this focus on Chávez has obscured the inner dynamics and historical development of the country’s Bolivarian Revolution. In We Created Chávez, by examining social movements and revolutionary groups active before and during the Chávez era, Ciccariello-Maher provides a broader, more nuanced account of Chávez’s rise to power and the years of activism that preceded it. Based on interviews with grassroots organizers, former guerrillas, members of neighborhood militias, and government officials, Ciccariello-Mah...
Raising Heirs to the Throne in Nineteenth-Century Spain
This book analyses royal education in nineteenth-century, constitutional Spain. Its main subjects are Isabel II (1830- 1904), Alfonso XII (1857-1885) and Alfonso XIII (1886-1941) during their time as monarchs-in-waiting. Their upbringing was considered an opportunity to shape the future of Spain, reflected the political struggles that emerged during the construction of a liberal state, and allowed for the modernisation of the monarchy. The education of heirs to the throne was taken seriously by contemporaries and assumed wider political, social and cultural significance. This volume is structured around three powerful groups which showed an active interest, influenced, and significantly shaped royal education: the court, the military, and the public. It throws new light on the position of the Spanish monarchy in the constitutional state, its ability to adapt to social, political, and cultural change, and its varied sources of legitimacy, power, and attraction.
Operative Cranial Neurosurgical Anatomy
One-of-kind textbook provides comprehensive tutorial on cranial anatomy with step-by-step text and visuals Dissection in the anatomical laboratory is a mandatory component of training for neurosurgeons. Acquisition of highly technical skills is a long and arduous task, requiring knowledge of complex surgical anatomy and basic steps for single surgical approaches. Unlike dense textbooks, Operative Cranial Neurosurgical Anatomy by Filippo Gagliardi, Cristian Gragnaniello, Pietro Mortini, and Anthony Caputy provides readers with a user-friendly tutorial on cranial approaches, clearly delineated through concise written instructions and serial images. Essential procedural aspects are discussed in...
Developmental Biology Protocols
Developmental biology is one of the most exciting and fast-growing fields today. In part, this is so because the subject matter deals with the innately fascinating biological events—changes in form, structure, and function of the org- ism. The other reason for much of the excitement in developmental biology is that the field has truly become the unifying melting pot of biology, and provides a framework that integrates anatomy, physiology, genetics, biochemistry, and cellular and mole- lar biology, as well as evolutionary biology. No longer is the study of embryonic development merely “embryology.” In fact, development biology has produced - portant paradigms for both basic and clinical...
Sphingolipids and Metabolic Disease
Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.
Bioactive Sphingolipids in Cancer Biology and Therapy
This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.
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