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Telomeres
Telomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres. The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here. Two chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.
Photochemistry and Photobiology of Nucleic Acids
Photochemistry and Photobiology of Nucleic Acids, Volume I: Chemistry covers the historical developments in the study of photobiology and photochemistry of nucleic acid components. This volume is divided into 12 chapters that deal with the isolation and characterization of ultraviolet photoproducts of pyrimidines. After briefly covering the concepts of photochemistry of nucleic acids, this volume goes on describing the UV-induced physical and chemical alterations in nucleic acid components, such as pyrimidines, purines, their nucleosides and nucleotides, and related compounds. Significant chap ...
Les télomères
’évolution a doté les organismes eucaryotes de chromosomes linéaires, équipant chaque chromosome d’extrémités qui sont protégées par une structure particulière nommée « télomère ». L’effet considérable des télomères sur la stabilité globale du génome et leur implication dans le vieillissement et le cancer ont contribué à leur fascination. Cet ouvrage présente les télomères en tant qu’exemple de diversité et d’unité du vivant, à travers les nombreux modèles qui y sont décrits (ciliés, levures, cellules humaines ou modèle souris). Dans la première partie, les auteurs introduisent l’histoire de leur découverte, leurs rôles biologiques, leurs aspects structuraux (séquences, longueur, protéines du complexe shelterine, structures G4 et T-loop, compaction et ancrage) et fonctionnels (réplication, transcription, maintien). La seconde partie explore leurs dysfonctionnements, les conséquences sur la santé humaine et les approches thérapeutiques. Les télomères est rédigé par des chimistes, biochimistes, structuralistes et biologistes illustrant ainsi l’interdisciplinarité de l’étude des télomères.
Practical Bioinformatics
Bridges the gap between bioinformaticists and molecular biologists, i.e. the developers and the users of computational methods for biological data analysis and in that it presents examples of practical applications of the bioinformatics tools in the "daily practice" of an experimental research scientist.
Fluorescent Analogs of Biomolecular Building Blocks
Fluorescent Analogs of Biomolecular Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.
Community-Based Health Interventions
Community-Based Health Interventions covers the skills necessary to change health in a community setting through the reduction of disease, disease conditions, and risks to health, as well as create a supportive environment for the maintenance of the behavior changes. The first section provides background information about why interventions in communities are important, the history of several major community interventions, ethical issues in the design and implementation of interventions and the different types of interventions. The second section covers planning and activities needed to complete an intervention, along with the theoretical basis of interventions. The third section shows how to...
The Molecules of Life
This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.
