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Telomeres
Telomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres. The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here. Two chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.
Les télomères
’évolution a doté les organismes eucaryotes de chromosomes linéaires, équipant chaque chromosome d’extrémités qui sont protégées par une structure particulière nommée « télomère ». L’effet considérable des télomères sur la stabilité globale du génome et leur implication dans le vieillissement et le cancer ont contribué à leur fascination. Cet ouvrage présente les télomères en tant qu’exemple de diversité et d’unité du vivant, à travers les nombreux modèles qui y sont décrits (ciliés, levures, cellules humaines ou modèle souris). Dans la première partie, les auteurs introduisent l’histoire de leur découverte, leurs rôles biologiques, leurs aspects structuraux (séquences, longueur, protéines du complexe shelterine, structures G4 et T-loop, compaction et ancrage) et fonctionnels (réplication, transcription, maintien). La seconde partie explore leurs dysfonctionnements, les conséquences sur la santé humaine et les approches thérapeutiques. Les télomères est rédigé par des chimistes, biochimistes, structuralistes et biologistes illustrant ainsi l’interdisciplinarité de l’étude des télomères.
Protein Synthesis and Ribosome Structure
Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.
The Molecules of Life
This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.
Practical Bioinformatics
This book presents applications of bioinformatics tools that experimental research scientists use in "daily practice." Its interdisciplinary approach combines computational and experimental methods to solve scientific problems. The book begins with reviews of computational methods for protein sequence-structure-function analysis, followed by methods that use experimental data obtained in the laboratory to improve functional predictions.
Marine Biology
Philip Mladenov provides a comprehensive overview of marine biology, providing a tour of marine life and marine processes that ranges from the polar oceans to tropical coral reefs; and from the intertidal to the hydrothermal vents of the deep sea.
The Biology Book
Learn about the most important discoveries and theories of this science in The Biology Book. Part of the fascinating Big Ideas series, this book tackles tricky topics and themes in a simple and easy to follow format. Learn about Biology in this overview guide to the subject, brilliant for novices looking to find out more and experts wishing to refresh their knowledge alike! The Biology Book brings a fresh and vibrant take on the topic through eye-catching graphics and diagrams to immerse yourself in. This captivating book will broaden your understanding of Biology, with: - More than 95 ideas and events key to the development of biology and the life sciences - Packed with facts, charts, timel...
I Contain Multitudes
THE NEW YORK TIMES BESTSELLER FROM THE WINNER OF THE 2021 PULITZER PRIZE Your body is teeming with tens of trillions of microbes. It's an entire world, a colony full of life. In other words, you contain multitudes. They sculpt our organs, protect us from diseases, guide our behaviour, and bombard us with their genes. They also hold the key to understanding all life on earth. In I Contain Multitudes, Ed Yong opens our eyes and invites us to marvel at ourselves and other animals in a new light, less as individuals and more as thriving ecosystems. You'll never think about your mind, body or preferences in the same way again. 'Super-interesting... He just keeps imparting one surprising, fascinating insight after the next. I Contain Multitudes is science journalism at its best' Bill Gates SHORTLISTED FOR THE WELLCOME BOOK PRIZE 2017 SHORTLISTED FOR THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2017
