Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Precision Medicine: Impact of Cytochromes P450 and Transporters Genetic Polymorphisms, Drug-Drug Interactions, Disease on Safety and Efficacy of Drugs
Topic Editor Professor Amin Rostami is the Senior Vice President of Research & Development and Chief Scientific Officer at Certara. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Impact des cytochromes P450 2D6 et 3A sur les paramètres pharmacocinétiques et pharmacodynamiques de l'oxycodone
L'oxycodone est respectivement N- et O-déméthylée par les CYP3A et 2D6. Nous avons évalué leur contribution dans la pharmacocinétique et pharmacodynamie de l'oxycodone, et notamment son efficacité antinociceptive, dans une étude randomisée contrôlée croisée chez 10 volontaires sains génotypés (2PM-IM, 6EM, 2UM pour le CYP2D6). Les 5 séances étaient: placebo, oxycodone 0,2 mg/kg 2h après quinidine 100 mg et/ou kétoconazole 400 mg et/ou placebo. La naloxone était injectée 2h après. La pharmacocinétique (suivie sur 24h), la pharmacodynamie (6h) et les phénotypes (CYP2D6 et 3A) ont été évalués. Après oxycodone, l'activité pharmacodynamique (analgésie, toxicité) est accrue chez les UM alors que ces effets sont réduits chez les PM-IM. Le kétoconazole augmente la magnitude des effets pharmacodynamiques et la quinidine les réduit. La naloxone renverse les effets observés. Le génotype pour le CYP2D6 et les interactions médicamenteuses via les CYP2D6/3A ont une influence majeure sur la cinétique, l'effet analgésique et la sécurité de l'oxycodone.
Australia's Secret War
Hal Colebatch's new book, AUSTRALIA'S SECRET WAR, tells the shocking, true, but until now largely suppressed and hidden story of the war waged from 1939 to 1945 by a number of key Australian trade unions against their own society and against the men and women of their own country's fighting forces at the time of its gravest peril. His conclusions are based on a broad range of sources, from letters and first-person interviews between the author and ex-servicemen to official and unofficial documents from the archives of World War II. Between 1939 and 1945 virtually every major Australian warship, including at different times its entire force of cruisers, was targeted by strikes, go-slows and sabotage. Australian soldiers operating in New Guinea and the Pacific Islands went without food, radio equipment and munitions, and Australian warships sailed to and from combat zones without ammunition, because of strikes at home. Planned rescue missions for Australian prisoners-of-war in Borneo were abandoned because wharf strikes left rescuers without heavy weapons. Officers had to restrain Australian and American troops from killing striking trade unionists.
Self Portrait in Green
'NDiaye is a hypnotic storyteller with an unflinching understanding of the rock-bottom reality of most people's life.' New York Times ' One of France's most exciting prose stylists.' The Guardian. Obsessed by her encounters with the mysterious green women, and haunted by the Garonne River, a nameless narrator seeks them out in La Roele, Paris, Marseille, and Ouagadougou. Each encounter reveals different aspects of the women; real or imagined, dead or alive, seductive or suicidal, driving the narrator deeper into her obsession, in this unsettling exploration of identity, memory and paranoia. Self Portrait in Green is the multi-prize winning, Marie NDiaye's brilliant subversion of the memoir. Written in diary entries, with lyrical prose and dreamlike imagery, we start with and return to the river, which mirrors the narrative by posing more questions than it answers.
Non-Biological Complex Drugs
The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.
Home Reading Service
In this poignant novel, a man guilty of a minor offense finds purpose unexpectedly by way of his punishment—reading to others. After an accident—or “the misfortune,” as his cancer-ridden father’s caretaker, Celeste, calls it—Eduardo is sentenced to a year of community service reading to the elderly and disabled. Stripped of his driver’s license and feeling impotent as he nears thirty-five, he leads a dull, lonely life, chatting occasionally with the waitresses of a local restaurant or walking the streets of Cuernavaca. Once a quiet town known for its lush gardens and swimming pools, the “City of Eternal Spring” is now plagued by robberies, kidnappings, and the other myriad ...
