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Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench
Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths related to dengue, mainly in children. Recent estimates show higher numbers, up to three times more, with 390 million estimated dengue infections per year, among which 96 million apparent infections (Bhatt et al. 2013). Initially localized to South-East Asia, dengue virus (DENV) started its spread in Latin America in the 80’s. Little is known about DENV spread in Africa, but multiple seroprevalence ...
Etude des cellules NK au cours des infections par le virus du Chikungunya et le virus de la Dengue
Les virus du Chikungunya (CHIKV) et de la dengue (DENV) sont deux virus émergents qui sévissent dans les régions tropicales et subtropicales du monde entier et qui sont transmis par les moustiques du genre Aedes. Ces dernières années, leur transmission a surtout progressé dans les zones urbaines et périurbaines touchant des millions d'individus et faisant de ces deux pathogènes des sujets majeurs de préoccupation pour la santé publique. Le Chikungunya et la Dengue sont des infections dites aiguës entrainant une mise en place rapide de la réponse immunitaire innée qui joue un rôle majeur dans le contrôle et l'évolution de la maladie. Les cellules Natural Killer (NK) représent...
Revolutionary Republicanism
Revolutionary Republicanism provides a history of French republicanism seen through a seminal episode of its creation – the 1848 revolution. The process of reinventing republicanism in 1848 gave rise to two opposite understandings of republicanism: a moderate one that merely adapted the institutions of representative government to popular sovereignty, and a more radical, ‘social- democratic’ notion of republicanism, based on inclusive forms of representation and aiming at the emancipation of the proletariat. These two notions of republicanism unfolded over the course of the few critical months between the revolution of February 1848 and the uprising of June 1848, which saw the victory ...
Bulletin des lois. Partie supplémentaire
Bulletin des lois, 2e partie. Ordonnances, 1e et 2e section
