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Stereotactic and Functional Neurosurgery
Since its introduction about sixty years ago, stereotactic and functional neurosurgery has evolved into a fascinating and interdisciplinary endeavor that combines modern neurosurgery, neurobiology, and neuroimaging with innovative diagnostic and treatment strategies. In this collection, acknowledged experts from Europe and North and South America present their scientific and clinical experience in stereotactic and functional neurosurgery for movement disorders and brain tumors. The contributions present a wide range from the beginnings of human stereotactic neurosurgery to the most modern molecular and restorative strategies to treat diseases of the human nervous system. They clearly demonstrate that the discipline is still young and dynamic with alternative and sometimes competing strategies whose evaluation is underway. They also document that operative lesioning techniques such as thalamotomies, though still chosen under certain circumstances, have been succeeded by novel neuromodulation techniques such as deep brain stimulation in the great majority of clinical cases.
Basal ganglia: physiological, behavioral, and computational studies
The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research—in both animals and humans—attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.
Pattern Recognition
This book constitutes the refereed proceedings of the 36th German Conference on Pattern Recognition, GCPR 2014, held in Münster, Germany, in September 2014. The 58 revised full papers and 8 short papers were carefully reviewed and selected from 153 submissions. The papers are organized in topical sections on variational models for depth and flow, reconstruction, bio-informatics, deep learning and segmentation, feature computation, video interpretation, segmentation and labeling, image processing and analysis, human pose and people tracking, interpolation and inpainting.
Sexual Dysfunction in Parkinson's Disease
Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Updated release includes the latest information regarding Sexual Dysfunction in Parkinson's Disease
Cholesterol, Lipoproteins, and Cardiovascular Health
Discover the biology, biochemistry, and medical aspects of lipoproteins in this comprehensive overview of its historic and contemporary development The fatty substance known as cholesterol is found in every cell of the human body and carries out several important functions. It is transported through the bloodstream as a part of particles called lipoproteins, which are divided into classes including low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Distinguishing between these two classes, along with the ‘remnant cholesterol’ particles that have recently been associated with heightened risk of heart disease and stroke, is a crucial part of managing health and developing no...
Amyotrophe Lateralsklerose und andere Motoneuronerkrankungen
There has been a fundamental revolution of our understanding of ALS in recent years. It is a multisystem neuromuscular disease that has a neurodegenerative basis which, along with the frontotemporal dementias, represents a spectrum of conditions. Cognitive and behavioural disorders are now an integral part of the diagnostic criteria, and initial diagnostic biomarkers have been established. This has significant implications not only for the diagnosis, treatment and care of patients, but also for our understanding of the pathophysiology of the disease. Rapidly advancing technical developments, such as eye control&based communication, are creating novel opportunities for therapists, patients and their relatives, which are increasingly influencing borderline decisions for and against life-prolonging measures. This book takes account of these new developments and develops novel concepts ranging from basic science to the classification and diagnosis of the disease to the opportunities and limitations of current and future treatment options and approaches to care.
Amyotrophe Lateralsklerose (ALS)
Prof. Thomas Meyer is a neurologist and is the Director of the ALS Outpatient Department of Charité & Universitätsmedizin Berlin. He has been working with ALS patients since 1991. Research visits have taken him to the California Pacific Medical Center in San Francisco, to Mount Sinai School of Medicine in New York and to the Max Delbrück Centre for Molecular Medicine in Berlin. He completed his neurological training at the Charité and at the University of Ulm. His doctoral and postdoctoral degrees were concerned with molecular-genetic issues in ALS. In 2002, he founded the ALS Outpatient Department at the Charité, which has developed into a specialized care and study center. He is co-founder of the care and research platform ?Ambulanzpartner= and author of numerous scientific publications on ALS.
Neurobiologie der Abhängigkeit
Die Erforschung der neurobiologischen Aspekte von Suchterkrankungen dient dem Verständnis der Krankheitsursachen, deren spezifischer Behandlung und der Entstigmatisierung der betroffenen Menschen. Der Band stellt die Leitsymptome von Abhängigkeitserkrankungen vor, bezieht diese auf ihre neurobiologischen Grundlagen und diskutiert die Übereinstimmungen und Unterschiede zwischen den verschiedenen Suchterkrankungen. Ausführlich werden Störungen im sog. dopaminergen Belohnungssystem und ihre Auswirkungen auf die GABAerge und glutamaterge Neurotransmission beschrieben. Weiterhin werden Störungen der serotonergen Neurotransmission und ihre Bedeutung für die Affektivität ebenso wie Veränderungen der Opioidrezeptoren diskutiert. Kapitel zu den genetischen Grundlagen der jeweiligen Suchterkrankungen und den therapeutischen Implikationen der neurobiologischen Befunde runden das Buch ab.
Schluckdiagnostik
This practically oriented casebook presents the currently available methods of swallowing diagnosis and typical findings in neurogenic dysphagia on the basis of case reports. Rarer forms, such as myasthenia gravis and Miller Fisher syndrome, as well as dysphagia of nonneurogenic origin & for example, in COPD, ventral cervical spondylopathy, and head and neck tumors & are also discussed. Fiberoptic endoscopic evaluation of swallowing (FEES) is an essential part of the section on diagnosis, complemented in some cases by videofluoroscopic or gastroenterologic findings in order to present important differential-diagnostic aspects as well. The original videos for the total of 22 case reports are available online as supplementary material.
Neurogene Dysphagien
Neurological diseases such as cerebral stroke, dementia, and Parkinson=s disease are the most frequent causes of swallowing disturbances. Neurogenic dysphagias are playing an increasingly important role in outpatient and in-patient care due to their often severe health sequelae and the increasing ageing of the population. In a practically oriented way, this established reference work discusses the neurophysiological basis, as well as the diagnosis and treatment of neurogenic dysphagias, reflecting the rapid developments in this field during the last 15 years. A special focus in the book is carrying out and reporting on the endoscopic evaluation of neurogenic dysphagias. Since 2015, the German Association for Neurology and the German Stroke Association have been offering a Flexible Endoscopic Examination of Swallowing (FEES) training curriculum for neurogenic dysphagias, and the German Association for Geriatric Medicine has also joined with the project. All of the content requirements for the FEES training curriculum are covered in this expanded and revised second edition of the book. Example FEES videos for various patterns of disturbance can be downloaded as additional materials.
