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Disease and the Hippo Pathway
The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
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Medium Companies of Europe 1990/91
VOLUMES 1 &2 Graham & Trotman, a member of the Kluwer Academic Publishers Group is one of Europe's leading publishers MEDIUM COMPANIES OF EUROPE 1990/91, Volume 1, of business information, and publishes company contains useful information on over 3500 of the most reference annuals on other parts of the world as follows: important medium-sized companies in the European Economic Community, excluding the UK, nearly 1500 MAJOR COMPANIES OF THE ARAB WORLD companies of which are covered in Volume 2. Volume 3 MAJOR COMPANIES OF THE FAR EAST & covers nearly 2000 of the medium-sized companies AUSTRALASIA within Western Europe but outside the European MAJOR COMPANIES OF THE U.S.A. Economic Community. ...
Consumer Europe
A compendium of market information on major consumer goods purchased in West European countries.
Excavating Women
Archaeologists are increasingly aware of issues of gender when studying past societies; women are becoming better represented within the discipline and are attaining top academic posts. However, until now there has been no study undertaken of the history of women in European archaeology and their contribution to the development of the discipline. Excavating Women discusses the careers of women archaeologists such as Dorothy Garrod, Hanna Rydh and Marija Gimbutas, who against all odds became famous, as well as the many lesser-known personalities who did important archaeological work. The collection spans the earliest days of archaeology as a discipline to the present, telling the stories of w...
Management of Severe Traumatic Brain Injury
In order to reduce the number of deaths from severe head injuries, systematic management is essential. This book is a practical, comprehensive guide to the treatment of patients (both adults and children) with such injuries, from the time of initial contact through to the rehabilitation center. Sections are devoted to prehospital treatment, admission and diagnostics, acute management, and neurointensive care and rehabilitation. Evidence-based recommendations are presented for each diagnostic and therapeutic measure, and tips, tricks, and pitfalls are highlighted. Throughout, the emphasis is on the provision of sound clinical advice that will maximize the likelihood of an optimal outcome. Helpful flowcharts designed for use in daily routine are also provided. The authors are all members of the Scandinavian Neurotrauma Committee and have extensive practical experience in the areas they write about.
