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Cancer Immunotherapy Meets Oncology
This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
Immune responses to AAV vectors, from bench to bedside
The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic. Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gen...
Master Musicians - Britten
For the revised edition of his highly-praised study of the composer, Michael Kennedy included new material on Britten's life which had recently become available. He also added a new chapter on Britten's posthumously published works. All the reference sections were updated, including thediscography of Britten's performances of his own works.
The Music of Britten and Tippett
In this classic study of Benjamin Britten and Michael Tippett, Arnold Whittall builds up a unique double portrait of the two leading composers of their generation. For this second, revised edition Whittall includes a new chapter on Tippett's major works of the 1980s: the Piano Sonata No. 4, the large-scale choral composition The Mask of Time and the most recent opera, New Year. In addition, new information on the Britten repertoire and an updated bibliography are also presented.
20th-century Composers
A portrait of the life and work of Benjamin Britten.
Benjamin Britten
Michael Wilcox's Outline takes a sidelong and challenging glance at Britten's operas from the theatrical point of a gay dramatist. Britten's output includes notable settings of poetry by Auden, Rimbaud, Michelangelo and Wilfred Owen--all homosexuals. But it is his magnificent operas which lie at the heart of his work; beneath the recurring theme of innocence corrupted, Wilcox explores their fascinating personal and private gay subtexts, ranging from camp innuendo to profound and secret emotions. He also recounts the story of Britten's relationships with his lover Peter Pears, and with his librettists, including W. H. Auden, E. M. Forster, Eric Crozier and Myfanwy Piper.
Purcell Remembered
Purcell was the greatest ornament of English music in the seventeenth century, and has been a source of inspiration for British composers ever since. Michael Tippett, Benjamin Britten and Peter Maxwell Davies are among those who have expressed indebtedness to Purcell's musical genius. But the person of Henry Purcell has seemed shadowy; in his day there were no newspapers to illuminate his career, no colour supplements to delve into Frances Purcell's sitting room. From the mass of assorted material that does exist Michael Burden has assiduously and cunningly devised a portrait of the composer both in his time and since, using diaries, letters and official and published writings from the seven...
The Marathon of the Messenger
The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to ...
Vaccinology
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
RNA Vaccines
This second edition volume expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs. The chapters in this book are organized into four parts and cover topics such as replication and non-replicating RNA vectors, formulation and delivery of RNA vaccines, and clinical and nonclinical development of RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, RNA Vaccines: Methods and Protocols, Second Edition is a valuable resource for any researcher interested in learning more about this important and developing field.
