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Cancer Immunotherapy Meets Oncology
This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
Immune responses to AAV vectors, from bench to bedside
The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic. Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gen...
The Marathon of the Messenger
The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to ...
Vaccinology
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
mRNA Vaccine
What Is mRNA Vaccine The immunological response that is induced by a vaccination known as an mRNA vaccine is brought about by the administration of a replica of a molecule known as messenger RNA (mRNA). The vaccine inserts molecules of mRNA that encode antigens into immune cells. The immune cells then utilize the engineered mRNA as a template to construct a foreign protein similar to one that would typically be generated by a cancer cell or a disease. These protein molecules activate an adaptive immune response, which educates the body to detect and eliminate the matching cancer cells or pathogens. Adaptive immune responses have been shown to be more effective than traditional immune respons...
mRNA Aşısı
mRNA Aşısı Nedir? MRNA aşısı olarak bilinen bir aşı tarafından indüklenen immünolojik yanıt, haberci olarak bilinen bir molekülün bir kopyasının uygulanmasıyla ortaya çıkar. RNA (mRNA). Aşı, antijenleri kodlayan mRNA moleküllerini bağışıklık hücrelerine yerleştirir. Bağışıklık hücreleri daha sonra, tipik olarak bir kanser hücresi veya bir hastalık tarafından üretilecek olana benzer bir yabancı protein oluşturmak için tasarlanmış mRNA'yı bir şablon olarak kullanır. Bu protein molekülleri, uyumlu kanser hücrelerini veya patojenleri tespit etmek ve ortadan kaldırmak için vücudu eğiten adaptif bir bağışıklık tepkisini aktive eder. Adaptif...
Vaccin ARNm
Qu'est-ce qu'un vaccin à ARNm La réponse immunologique induite par un vaccin connu sous le nom de vaccin à ARNm est provoquée par l'administration d'une réplique d'une molécule connue sous le nom de messager ARN (ARNm). Le vaccin insère des molécules d'ARNm qui codent des antigènes dans les cellules immunitaires. Les cellules immunitaires utilisent ensuite l'ARNm modifié comme matrice pour construire une protéine étrangère similaire à celle qui serait généralement générée par une cellule cancéreuse ou une maladie. Ces molécules protéiques activent une réponse immunitaire adaptative, qui éduque le corps à détecter et à éliminer les cellules cancéreuses ou pathogè...
Vacina mRNA
O que é vacina de mRNA A resposta imunológica que é induzida por uma vacinação conhecida como vacina de mRNA é provocada pela administração de uma réplica de uma molécula conhecida como mensageiro ARN (ARNm). A vacina insere moléculas de mRNA que codificam antígenos nas células imunes. As células imunes então utilizam o mRNA manipulado como modelo para construir uma proteína estranha semelhante a uma que normalmente seria gerada por uma célula cancerosa ou uma doença. Essas moléculas de proteína ativam uma resposta imune adaptativa, que educa o corpo para detectar e eliminar as células cancerígenas ou patógenos correspondentes. As respostas imunes adaptativas têm se m...
Vaccino mRNA
Cos'è il vaccino mRNA La risposta immunologica indotta da una vaccinazione nota come vaccino mRNA è determinata dalla somministrazione di una replica di una molecola nota come messaggero RNA (mRNA). Il vaccino inserisce molecole di mRNA che codificano gli antigeni nelle cellule immunitarie. Le cellule immunitarie utilizzano quindi l'mRNA ingegnerizzato come modello per costruire una proteina estranea simile a quella che verrebbe tipicamente generata da una cellula cancerosa o da una malattia. Queste molecole proteiche attivano una risposta immunitaria adattativa, che educa il corpo a rilevare ed eliminare le cellule cancerose o gli agenti patogeni corrispondenti. Le risposte immunitarie ad...
mRNA-Impfstoff
Was ist ein mRNA-Impfstoff Die immunologische Reaktion, die durch eine als mRNA-Impfstoff bekannte Impfung induziert wird, wird durch die Verabreichung einer Kopie eines Moleküls hervorgerufen, das als Messenger bekannt ist RNA (mRNA). Der Impfstoff fügt mRNA-Moleküle, die für Antigene kodieren, in Immunzellen ein. Die Immunzellen verwenden dann die manipulierte mRNA als Vorlage, um ein fremdes Protein zu konstruieren, das dem ähnelt, das typischerweise von einer Krebszelle oder einer Krankheit erzeugt wird. Diese Proteinmoleküle aktivieren eine adaptive Immunantwort, die den Körper dazu bringt, die passenden Krebszellen oder Krankheitserreger zu erkennen und zu eliminieren. Es hat si...
