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Cell Cycle Control
The fundamental question of how cells grow and divide has perplexed biologists since the development of the cell theory in the mid-19th century, when it was recognized by Virchow and others that “all cells come from cells.” In recent years, considerable effort has been applied to the identification of the basic molecules and mechanisms that regulate the cell cycle in a number of different organisms. Such studies have led to the elucidation of the central paradigms that underpin eukaryotic cell cycle control, for which Lee Hartwell, Tim Hunt, and Paul Nurse were jointly awarded the Nobel Prize for Medicine and Physiology in 2001 in recognition of their seminal contributions to this field. The importance of understanding the fundamental mechanisms that modulate cell division has been reiterated by relatively recent discoveries of links between cell cycle control and DNA repair, growth, cellular metabolism, development, and cell death. This new phase of integrated cell cycle research provides further challenges and opportunities to the biological and medical worlds in applying these basic concepts to understanding the etiology of cancer and other proliferative diseases.
Temporal Organization in Cells
For the scientist with a training in physics this book will offer no difficulties. The biological background which is required is minimal, and except for certain aspects of enzymology on the one hand and embryology on the other, the exposition is self-contained. Actually the physicist will probably find the mathematical treatment definitely lacking in the rigour to which they are accustomed. The attempt has been made to steer a middle course between physics and biology, thus making the material accessible to scientists with a training on either side.
Control Mechanisms in Cellular Processes
This volume on the control mechanisms in cellular processes consists of papers presented at the symposium of the Society of General Physiologists at its annual meeting in 1960. It will, we trust, prove useful as a report to the diverse mechanisms now known to act as regulatory systems.
Introduction to Modeling Biological Cellular Control Systems
This textbook contains the essential knowledge in modeling, simulation, analysis, and applications in dealing with biological cellular control systems. In particular, the book shows how to use the law of mass balance and the law of mass action to derive an enzyme kinetic model - the Michaelis-Menten function or the Hill function, how to use a current-voltage relation, Nernst potential equilibrium equation, and Hodgkin and Huxley's models to model an ionic channel or pump, and how to use the law of mass balance to integrate these enzyme or channel models into a complete feedback control system. The book also illustrates how to use data to estimate parameters in a model, how to use MATLAB to solve a model numerically, how to do computer simulations, and how to provide model predictions. Furthermore, the book demonstrates how to conduct a stability and sensitivity analysis on a model.
