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A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.
A comprehensive survey of nonsurgical treatment for a variety of heart diseases that affect the cardiac valves, the heart muscle, and the structure of the heart. The authors describe who these procedures are useful for, how to do them, and how well they work. Major topics of discussion include percutaneous techniques for valvular heart disease, septal defects at both the atrial and ventricular levels, adjunctive therapies during coronary interventions, and angioplasty to treat extracardiac vascular disease, as well as reviews of the cutting-edge imaging modalities now being used in interventional procedures. An accompanying CD-ROM contains video demonstrations of catheterization and and the imaging portions of these procedures.
M. Gabriel Khan, MD, concisely assembles in a reader friendly format all the clinically useful information that an internist needs in both his daily rounds and abusy office practice to find correct clinical diagnoses and choose optimal pharmacologic therapies for their patients. Highlights include a simplified method for recognition of, and a practical therapeutic approach to, arrhythmias, as well as a more logical approach to drug management of hypertension than that given by the Joint National Committee, instructive algorithms that simplify the diagnosis and treatment of syncope, and extensive diagnostic information on hypertrophic cardiomyopathy. A large number of illustrative electrocardiograms that help to clarify the most often misinterpreted of all cardiologic tests and extensive discussions of practical cardiovascular pharmacology complete this magisterial survey.
Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.
Over recent decades vast amounts of biological data have been accumulated. However, it is becoming increasingly difficult to apply traditional theoretical methods to the formulation of coherent pictures of cell and organ function because it is no longer possible for a human theorist to integrate all of the available information. Instead, computer technologies must now be used to perform this integration. This book brings together contributions from many different fields to summarize the current status of computer-assisted modelling of biological processes. The initial chapters deal with fundamental developments in hardware, software and mathematics that underlie current approaches to biologi...
The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient probl...
Long QT syndrome is a heart rhythm disorder that can cause fast, chaotic heartbeats. In some cases, long QT syndrome can cause sudden death. Long QT syndrome may result from a genetic mutation or be caused by certain medications and medical conditions. The condition is treatable with medication, surgery, or an implantable device. Because it may have serious consequences, it's important for electrophysiologists to know about long QT syndrome.
The goal of this book is to provide an integrated overview of some intriguing problems of cardiac electrophysiology. Topics have been selected that encompass mainly aspects which have been a matter of concern and interest in our Department over the past few years. We requested from the authors not only that they provide information about their own investiga tions, but also that they integrate their results with those published by oth ers. Furthermore, we urged them to be speculative in their interpretations in order to encourage exploration of related areas of investigation. To this end, the authors have presented their ,contributions in sufficient detail so that the information may not only...
This book explores the history of the Mayo Clinic Cardiac Catheterization Laboratory from 1940 to present day. It examines the life and journey of the Cardiac Catheterization Lab and its ultimate success in implementing the vision of the Mayo philosophy of emphasizing collaboration between lab-based scientists and clinical health care professionals to bring innovation to the clinical practice and lead landmark changes in the practice of medicine profoundly enhancing what we can offer to patients and society alike. The book is divided into decades, with separate sections in each decade on key cardiology topics such as congenital heart disease, coronary heart disease, hemodynamics, pacing, and...
This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.