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Long ago the world fell into twilight, when the great empires of old consumed each other in sorcerous cataclysms. In the south the Star Towers fell, swallowed by the sea, while the black glaciers descended upon the northern holdfasts, entombing the cities of Min-Ceruth in ice and sorcery. Then from the ancient empire of Menekar the paladins of Ama came, putting every surviving sorcerer to the sword and cleansing their taint from the land for the radiant glory of their lord. The pulse of magic slowed, fading like the heartbeat of a dying man. But after a thousand years it has begun to quicken again. In a small fishing village a boy with strange powers comes of age . . . A young queen rises in the west, fanning the long-smoldering embers of magic into a blaze once more . . . Something of great importance is stolen - or freed - from the mysterious Empire of Swords and Flowers . . . And the immortals who survived the ancient cataclysms bestir themselves, casting about for why the world is suddenly changing . . .
This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging...
"In 1591, Giovanni Paolo Gallucci published his Della simmetria dei corpi humani, an Italian translation of Albrecht Dürer's Four Books on Human Proportion. While Dürer's treatise had been translated earlier in the sixteenth-century into French and Latin, it was Gallucci's Italian translation that endured in popularity as the most cited version of the text in later Baroque treatises, covering topics that were seen as central to arts education, connoisseurship, patronage, and the wider appreciation of the studia humanitatis in general. The text centres on the relationships between beauty and proportion, macrocosm and microcosm: relationships that were not only essential to the visual arts i...
" ... [C]ollected stories on dozens of the league's most celebrated players."--Back cover
Sixteen essays ranging from lyric essays to narrative journalism address how we make sense of what we cannot know, how we make change in the world, how we heal, and how we know when we are home. Collectively, these essays convey the longing for agency and connection, particularly among women. They will resonate with readers of all ages, but perhaps especially with women in the second half of life, those dealing with aging parents, retirement, illness, and accompanying vulnerabilities. Here readers will find comfort within keen reflection upon life's ambiguities.
This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Previously published in 2020 by Amberley Publishing.
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