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Essential Guide to Irish Flute and Tin Whistle
For the beginner to the highly advanced player of Irish flute, tin whistle, or Boehm-system flute. Features a simple and penetrating new approach to understanding and notating ornamentation that goes beyond any previous method, exploring ornamentation techniques never described in print before. Also includes adaptations for Boehm-system flute players, guidance on breathing and phrasing, 49 ornamentation exercises, history and theory of traditional Irish flute and whistle music, and 27 meticulous transcriptions of recordings by these important Irish flute and tin whistle players: John McKenna,Tom Morrison, William Cummins, Séamus Ennis, Willie Clancy, Paddy Taylor, Paddy Carty, Grey Larsen, ...
Four Dead in Ohio
Tells the shocking story behind the cover-up of the May 4, 1970 slayings of four students at Kent State University.
Fragment-Based Drug Discovery
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
Geographies of Science
This collection of essays aims to further the understanding of historical and contemporary geographies of science. It offers a fresh perspective on comparative approaches to scientific knowledge and practice as pursued by geographers, sociologists, anthropologists, and historians of science. The authors explore the formation and changing geographies of scientific centers from the sixteenth to the twentieth centuries and critically discuss the designing of knowledge spaces in early museums, in modern laboratories, at world fairs, and in the periphery of contemporary science. They also analyze the interactions between science and the public in Victorian Britain, interwar Germany, and recent environmental policy debates. The book provides a genuine geographical perspective on the production and dissemination of knowledge and will thus be an important point of reference for those interested in the spatial relations of science and associated fields. The Klaus Tschira Foundation supports diverse symposia, the essence of which is published in this Springer series (www.kts.villa-bosch.de).
Successful Careers beyond the Lab
This book provides first-hand accounts of the many career opportunities open to graduates and postgraduates in the sciences and engineering beyond academic research.
Down the Back Lane: Variation in Traditional Irish Dance Music
From the author of The Essential Guide to Irish Flute and Tin Whistle comes a work for players of all melody instruments that probes deeply into the art of variation in traditional Irish dance music. At the heart of Down the Back Lane are the accompanying audio recordings. The author plays eight traditional tunes on Irish flute and tin whistle, each three timesthrough, complete with beautiful variations. He notates each performance inmeticulous detail and offers insightful comments on each one. We get a rare and intimate view into the intuitive musical mind of a masterful player, along with extensive information on ornamentation, phrasing, articulation, dynamics and much more.Though the author plays the tunes on flute and whistle, he has carefully designed the book to be useful to players of all melody instruments.
Computational and Structural Approaches to Drug Discovery
This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.
Fragment-based Drug Discovery
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
Quantum Chemistry Simulation of Biological Molecules
This book covers quantum chemical simulation of molecular systems and their quantum chemical properties, alongside the most cutting-edge biomedical applications.
