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In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.
The new edition of the most up-to-date, interdisciplinary history of Ohio currently available Now in its second edition, Ohio: A History of the Buckeye State surveys the long and rich history of Ohio from its earliest geological periods to the present day. Designed for undergraduate students and general readers alike, this accessible volume describes the pivotal events in Ohio’s history while discussing the major social, economic, and political trends that have shaped the state over time. Concise chapters cover Ohio prehistory and the First Ohioans, European contact, the formation of the Northwest Territory, early statehood and national politics, the Civil War, Reconstruction, the two Worl...
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The tea campaign as a case study -- Start-ups: creative concepts, not high-tech -- The step-child concept: it pays to finetune your concept -- Avoiding overload -- Building a business with components -- Playing in the big boys' league -- How to work out your own high-potential concept: the entrepreneurship laboratory -- Entrepreneurship as a challenge -- Say goodbye to old ways of thinking (don't draw conclusions about the future based on the past) -- An invitation to a dance
This treasury of facts and lore on the philosophy and practice of evil traces the concept of Satan from ancient to modern times. A collection of 350 rare and compelling images illuminate the text.
When Hitman Jack "The Pup" Stanton runs away with his mob boss's wife, he thinks he's finally put his murderous past behind him. Instead, Jack and his lover take a wrong turn into Silent Hill and quickly learn that some sins are impossible to escape!
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