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New Frontiers: Extracellular Vesicles
The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implic...
Connecting the Dots Between Inflammation and the Inner Workings of Programmed Cell Death
Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependen...
Luxusmarkenmanagement
Dieses Handbuch gibt einen Überblick über die Grundlagen und Besonderheiten der Luxusmarkenführung. Luxusunternehmen stehen kontinuierlich vor der schwierigen Aufgabe, ihre starken, von traditionellen Werten und handwerklicher Perfektion geprägten Luxusmarken innovativ und nachhaltig weiterzuentwickeln. Dafür ist es notwendig, die geeigneten Anpassungen vorzunehmen sowie die richtige Balance zu finden zwischen Tradition und Innovation und zwischen Exklusivität und Zugänglichkeit der Luxusmarke. Damit der „luxury dream“ wirksam werden kann, hat das Management und Marketing besonderen Regeln zu folgen. Die Darstellung dieser Spezifika sowie der Erfolgsfaktoren des Luxusmarkenmanagements ist das Ziel dieses Buches. Renommierte Autoren aus Wissenschaft und Praxis nehmen in 28 Beiträgen aus internationaler Perspektive Stellung zu aktuellen Herausforderungen und vermitteln, mit welchen Strategien und Instrumenten ein erfolgreiches Management der Luxusmarke möglich ist. /div
North Macedonia
Bradt's North Macedonia remains the only standalone English-language guidebook to this increasingly popular destination available outside the country. Originally written by Thammy Evans, a political analyst who lived in Macedonia for five years, this new edition has been thoroughly updated and restructured to make it even easier to use by Philip Briggs, arguably the world's most experienced guidebook writer. Coverage of national parks has been increased and hiking information has been fully integrated to make it more accessible to casual users. Introductions to many points of interest have been expanded to give more of an overview of what the attractions are and there are several new and red...
New Frontiers
The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implic...
Digital Media and the Dynamics of Civil Society
Based on an extended empirical research project, this book advances the theoretical, normative and practical understanding of civil society under the conditions of digital mediatization and in relation to a set of particular historical and geopolitical circumstances. Digital Media and the Dynamics of Civil Society adds to existing knowledge of the democratizing role of digital media in communication studies by carefully tracing the trajectory of the emergent communicative and representational practices of civil society in a pair of new European democracies – Estonia and Bulgaria – facing distinctive socio-cultural and political challenges. The book combines macro and micro perspectives t...
Predictability in Oil and Gas Investment Agreements
This rigorous book explores the opposing investor-state relationship and argues that a stable investment environment is achieved when the rights of both parties are recognised and balanced. Stanislava Nedeva examines how both certainty and predictability can be achieved in oil and gas investment agreements and identifies the ways in which political risks to contractual stability and indirect expropriation can be mitigated.
