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Development of Novel Routes and Methods for the Semisynthesis of the Marine Steroid Demethylgorgosterol and Unnatural Analogs
Gorgosterol and its derivative demethylgorgosterol are two long known marine steroids with unusual properties and a unique structure, containing a cyclopropane moiety in the side chain. Gorgosterol and its derivatives show diverse structural motives and biological activities. Moreover, corals and coral reefs have a tremendous ecological and economic impact but are endangered by climate change. A better understanding of corals can therefore aid their protection and conservation. A concise and high yielding formal semisynthesis for the marine steroid demethylgorgosterol was developed. Centerpiece was a stereoselective intermolecular cyclopropanation. A variety of demethylgorgosterol analogs were synthesized for biological applications. These include hydrocarbon analogs, diversely functionalized analogs, and fluorophore-steroid conjugates to track and visualize steroids in vivo. Finally, a new method for the synthesis of 3-cyclopropylacrylates was developed. Here, a vinylogous diazoester was utilized to cyclopropanate alkenes. The observed cis-selectivity was explained with π-π-interactions in the transition state.
Die Geschichte der Deutschen Gesellschaft in Leipzig
Der Band gibt erstmals eine ausführliche Darstellung der Geschichte der Deutschen Gesellschaft in Leipzig von ihren Anfängen (1697) bis zu ihrer Erneuerung unter der Leitung von Johann Christoph Gottsched (ca. 1730). Da die Leipziger Gesellschaft das Vorbild für die spätere Gründung zahlreicher gleichartiger Gesellschaften im gesamten deutschen Sprachgebiet abgab, ist die historiographische Erschließung ihrer Entwicklung eine Voraussetzung für die noch ausstehende intensivere Beschäftigung mit dem Sozietätstyp Deutsche Gesellschaft. In kritischer Auseinandersetzung mit der bisherigen Literatur wird gezeigt, daß die Geschichte der Gesellschaft bis zum Auftreten Gottscheds keineswegs...
Rituals of Retribution
The state has no greater power over its own citizens than that of killing them. This book examines the use of that supreme sanction in Germany, from the seventeenth century to the present. Richard Evans analyses the system of traditional' capital punishments set out in German law, and the ritual practices and cultural readings associated with them by the time of the early modern period. He shows how this system was challenged by Enlightenment theories of punishment and broke down under the impact of secularization and social change in the first half of the nineteenth century. The abolition of the death penalty became a classic liberal case which triumphed, if only momentarily, in the 1848 Re...
