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Druggable Lipid Signaling Pathways
Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulato...
The Insect Immune System as a Target for Protecting Beneficial Insects and Controlling Pests
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Historic Airports
The realisation of mankind's age-old dream of flight is probably one of the collective adventures that best characterises the century we have just left, its greatest novelty. In the space of only three or four generations aviation has conquered the entire planet and international airports have developed into sleepless cities. At the beginning of 1999, the European Commission sponsored an international project on aviation's architectural heritage, set up at the instigation of the French Ministry of Culture together with English Heritage and Landesdenkmalamt Berlin, the official heritage body of the German capital. The project's primary aim was to contribute to the better understanding and con...
Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
