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In April 2007, 62-year-old Eunice Spry was sentenced to 14 years in prison for the systematic wounding, cruelty and assault of the vulnerable children whose welfare had been entrusted to her. Her Gloucestershire home should have been a refuge. Instead it became a prison where, over the course of 20 years, her charges were routinely abused and tortured. To the outside world, Jehovah's Witness Spry presented herself as a pillar of the community. Behind closed doors she was a sadistic tyrant who beat the children with metal bars, forced wooden sticks down their throats and made them eat lard, bleach, vomit and faeces. The details of the trial horrified the nation, and attracted considerable pre...
You might think this story is an intergalactic adventure filled with laser blasters, black holes, killer robots and some very weird-looking aliens. And you'd be right. But it's mostly about a boy called Jake, his dad, and an awkward truth that starts in a supermarket ...
As a child, Victoria Spry was brutally beaten, neglected, and starved by the woman she called Mummy. To the outside world Eunice Spry was a devoted parent, but behind closed doors she was an evil tyrant. Instead of protecting, loving, and caring for Victoria, she forced bleach and urine down her throat, knocked out her teeth, tied her up naked, and made her live in squalor. It took 18 years of heartache and despair before she found the courage to expose her mum. Tortured is Victoria s gripping story of survival."
Evan Waller is a monster. He has built a fortune from his willingness to buy and sell anything . . . and anyone. In search of new opportunities, Waller has just begun a new business venture: one that could lead to millions of deaths all over the globe. On Waller's trail is Shaw, the mysterious operative from The Whole Truth, who must prevent Waller from closing his latest deal. Shaw's one chance to bring him down will come in the most unlikely of places: a serene, bucolic village in Provence. But Waller's depravity and ruthlessness go deeper than Shaw knows. And now, there is someone else pursuing Waller in Provence – Reggie Campion, an agent for a secret vigilante group headquartered in a musty old English estate – and she has an agenda of her own. Hunting the same man and unaware of each other's mission, Shaw and Reggie will be caught in a deadly duel of nerve and wits. Deliver Us From Evil is Hitchcockian in its intimate build-up of suspense and filled with the remarkable characters, breathtaking plot turns, and blockbuster finale that are David Baldacci's hallmarks.
Stephen Smith is the boy who did not exist. Born out of wedlock in the early 1960s, Steve's parents hid him away from the world by locking him in the cellar...for thirteen years. Starved and beaten, the little boy's world was a darkened room that measured just eight feet by ten with a single makeshift bed, bare light bulb, and a solitary table. Steve would spend his days conjuring up an imaginary world full of monsters he would draw to try and block out the physical and mental torture inflicted on him by his brutal father. Apart from a few admissions to hospital as a result of his 'imprisonment', Steve remained in the coal cellar of the family home where he was deprived of daylight, his childhood, school, and human contact until he'd reached his teenage years. Eventually, he escaped only to fall prey to the instigators of two of the worst cases of institutional abuse in the UK at Aston Hall hospital and St. William's Catholic School. The Boy in the Cellar is a horrifying true story of torture and cruelty, that reveals a human's full capacity to fight for survival and search out happiness and hope.
Describes how throughout history men's facial hair has varied in response to changing ideals of masculinity.
National Magazine Award finalist Christopher Howard's debut novel, Tea of Ulaanbaatar, tells the story of disaffected Peace Corps volunteer Warren, who flees life in late-capitalist America to find himself stationed in the post-Soviet industrial hell of urban Mongolia. As the American presence crumbles, Warren seeks escape in tsus, the mysterious "blood tea" that may be the final revenge of the defeated Khans—or that may be only a powerful hallucinogen operating on an uneasy mind—as a phantasmagoria of violence slowly envelops him. With prose that combines Benjamin Kunkel's satiric bite, William Burroughs’s dark historical reimagining, and a lush literary beauty all his own, Christopher Howard in Tea of Ulaanbaatar unfolds a story of expatriate angst, the dark side of globalization, and middle-class nightmares—and announces himself as one of the most inventive and ambitious of the new generation of American novelists.
#1 INSTANT NATIONAL BESTSELLER NEW YORK TIMES BESTSELLER THE TIMES (LONDON) THRILLER OF THE YEAR PICK AN INDIGO BEST BOOK OF THE YEAR NOMINATED for The Wilbur Smith Adventure Writing Prize and the Sideways Award for Alternate History "Exciting." —Andy Weir, author of The Martian "Nail-biting." —James Cameron, writer and director of Avatar and Titanic "Not to be missed." —Frederick Forsyth, author of The Day of the Jackal An exceptional Cold War thriller from the dark heart of the Space Race, by astronaut and bestselling author Chris Hadfield. 1973. A final, top-secret mission to the Moon. Three astronauts in a tiny module, a quarter of a million miles from home. A quarter of a million ...
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
'The Devil's Advocate' brings a fresh approach to the do's and don'ts of good advocacy. Written with humour and style, the title explains clear techniques, taking the reader through the practical application of advocacy step-by-step.