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Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development, Progression, and Treatment
In line with recent evidence, the development of cancer has been described as uncontrolled cell growth that results from gradual accumulation of genetic and epigenetic alterations, involving aberrations in oncogenes, tumor suppressor genes, and defects in genes engaged in DNA repair. As a result, cancer cells acquire a neoplastic phenotype and tumor-associated antigens (TAAs) are presented on their surface. These target structures should be recognized by cells of the immune system. However, a sequence of events at the genetic and epigenetic level disturb immune cells, and in consequence, make them unable to eliminate cancer cells. Both innate and adaptive immunity are mobilized against cance...
Novel Molecular Targets and Treatments for Gastroesophageal Cancer
Gastroesophageal cancer is among the most common malignant diseases worldwide and is associated with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Chemotherapeutic drugs have achieved great success in the treatment of esophageal cancer; however, they also bring cytotoxicity to other organs and often have serious side effects. With the development of molecular diagnostics and biomarker discovery, the application of precision medicine has emerged to improve clinical outcomes.
Seeking Truth in International TV News
This book puts CGTN (formerly CCTV-News) and the BBC’s international television news head-to-head, interrogating competing ‘truths’ in the exacting business of news reporting. Written by a media scholar and former long-serving BBC News journalist, Seeking Truth in International TV News asks if China’s English-language television news programmes are little more than state propaganda, and if the BBC can be viewed as a universal news standard to which all other broadcasters should aspire. Over 8 years of Xi Jinping’s rule, it investigates how the international TV news channels of CGTN and the BBC reported on Chinese politics, protests in Hong Kong, disasters, China in Africa, and insu...
Claiming Diaspora
This book addresses the increasingly plural nature of American cultural identity thrugh a study of the thriving contemporary music culture of Chinese America, ranging from traditional opera to Cantonese pop and from storytelling songs about the immigrant experience to the work of academically trained composers.
