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Heterogeneity in Breast Cancer: Clinical and Therapeutic Implications
Breast cancer is a highly heterogeneous disease. Despite advances in early detection and treatment, breast cancer (BC) is the leading cause of cancer death in women worldwide. Heterogeneity negatively affects a patient’s prognosis, treatment sensitivity, and clinical outcome. In particular, the development of drug resistance mechanisms and the failure of anticancer drugs (initially or subsequently) could lie in the heterogeneity among BC patients and tumors. The major international guidelines have adopted an immunophenotypic sub-classification of BC to maximize patient eligibility for personalized therapy but do not take into account the extreme diversity existing between breast tumors (intratumor heterogeneity).
AACR 2019 Proceedings: Abstracts 2749-5314
American Association for Cancer Research 2019 Proceedings: Abstracts 2749-5314 - Part B
Voltage Gated Sodium Channels
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Fiber Optic Sensors
This book presents a comprehensive account of recent advances and researches in fiber optic sensor technology. It consists of 21 chapters encompassing the recent progress in the subject, basic principles of various sensor types, their applications in structural health monitoring and the measurement of various physical, chemical and biological parameters. It also highlights the development of fiber optic sensors, their applications by providing various new methods for sensing and systems, and describing recent developments in fiber Bragg grating, tapered optical fiber, polymer optical fiber, long period fiber grating, reflectometry and interefometry based sensors. Edited by three scientists with a wide knowledge of the field and the community, the book brings together leading academics and practitioners in a comprehensive and incisive treatment of the subject. This is an essential reference for researchers working and teaching in optical fiber sensor technology, and for industrial users who need to be aware of current developments and new areas in optical fiber sensor devices.
Languages of Discrimination and Racism in Twentieth-Century Italy
This volume represents one of the first extensive studies that investigates the persistence of questions of race and racism in Italy from the liberal age to the present, through colonialism, Fascism and post-war Italy. It adopts an interdisciplinary perspective to investigate the intertwining of the cultural, social, legislative and political dynamics of discrimination in Italy’s past and present. Drawing upon the expertise of historians, political scientists, sociologists, scholars of literature and experts in cultural studies, the original essays collected in this volume show a remarkable continuity and the persistence of racism in the Italian cultural and political discourse, in society and in the representation of Others. They also speak of the shifting of practices of Othering from one group to another in different historical contexts.
A Place in the Sun
"This impressive volume succeeds in bringing Italian colonialism into the space of today’s most important debates regarding colonialism and multiculturalism."—Graziela Parati, author of Mediterranean Crossroads "A significant collection that really has no equal to date. The essays in this volume investigate profoundly the relationship between Italian colonialism and Italian society, past and present."—Anthony Tamburri, author of A Semiotic of Rereading
