Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Proteinase and Peptidase Inhibition
Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the
Nucleoside Mimetics
Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites. Nucleoside Mimetics provides an introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic and asymmetric synthesis. The book gives a comprehensive introduction to nucleosides and coverage of the various classes. The aim of Nucleoside Mimetics is to provide the reader with a useful insight into the diversity of nucleosides, the range of elegant chemistry involved and the continuing importance of nucleosides as both therapeutic agents and as probes for studying biochemical processes.
Protein Misfolding in Neurodegenerative Diseases
Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.
Enzymes and Their Inhibitors
Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease mar
Design of Caspase Inhibitors as Potential Clinical Agents
Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including: Arthritic and neurological disorders Lung disease He...
Artists on the Art of Survival
From across the spectrum of the arts--theater to music, painting to poetry, and everything in between--men and women from the creative front lines share their experiences and insights on the often harsh realities of a life in the arts. Artists on the Art of Survival examines the lives of artists as some continue to struggle to find their place, others have managed to carve out a niche for themselves, and still others have, for a variety of reasons, moved on to something else. By exploring each of these paths of development, the book provides valuable, practical, and spiritual lessons in maintaining and surviving as a working artist.
A Family Affair
Claire Simons is desperate to host a normal family get-together for Christmas. The trouble is, she just doesn't have a normal family. After fifteen years of marriage, her husband Gregg has walked out on her for Verity, an ambitious, young woman who wears startlingly short skirts. When her daughter Sadie throws a classic pre-teen strop about not being able see her father on Christmas Day, Claire decides she may have to put the past behind her - and resolves they must all spend the day together as a family. After blaming herself for months for stifling Gregg's free-spirit, and pushing him away, Claire decides she ready to face him and let go of her pain and anger. But when Robert Carrington, a...
Legacy of the Lancasters
Young or old, everyone has heard of the Lancaster bomber. Such is the legacy handed down by this aviation icon that although it is not the most numerous aircraft ever built - two are still flying today, one in Britain and another in Canada with many proudly displayed in museums throughout the world - it is up there with the Spitfire and the Flying Fortress in terms of affection, nostalgia and lasting fame. The legendary Lancaster has bequeathed to the world an invaluable heritage beloved of generations of movie-goers, air show enthusiasts, readers of fine literature and historians alike. Exploits such as the famous low-level raid by 617 Squadron on Germanys hydro electric dams on the night...
Smith and Williams' Introduction to the Principles of Drug Design and Action
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
