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Nucleoside Mimetics
Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites.An introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic, and asymmetric synthesis, this book examines the diversity of nucleosides and the range of elegant chemistry involved. It emphasizes the importance of nucleosides as both therapeutic agents and as probes for studying biochemical processes.
Protein Misfolding in Neurodegenerative Diseases
Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.
Design of Caspase Inhibitors as Potential Clinical Agents
Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including: Arthritic and neurological disorders Lung disease He...
Artists on the Art of Survival
From across the spectrum of the arts--theater to music, painting to poetry, and everything in between--men and women from the creative front lines share their experiences and insights on the often harsh realities of a life in the arts. Artists on the Art of Survival examines the lives of artists as some continue to struggle to find their place, others have managed to carve out a niche for themselves, and still others have, for a variety of reasons, moved on to something else. By exploring each of these paths of development, the book provides valuable, practical, and spiritual lessons in maintaining and surviving as a working artist.
The Trigger Point Therapy Workbook
Trigger point therapy is one of the fastest-growing and most effective pain therapies in the world. Medical doctors, chiropractors, physical therapists, and massage therapists are all beginning to use this technique to relieve patients’ formerly undiagnosable muscle and joint pain, both conditions that studies have shown to be the cause of nearly 25 percent of all doctor visits. This book addresses the problem of myofascial trigger points—tiny contraction knots that develop in a muscle when it is injured or overworked. Restricted circulation and lack of oxygen in these points cause referred pain. Massage of the trigger is the safest, most natural, and most effective form of pain therapy....
The Complete Idiot's Guide to the Perfect Resume, 5th Edition
Resumé: revamped for the times, technology, and the recession... The recession has made finding a job harder than ever. Everything now takes place online, and a resumé's preparation is different than even a few years ago. This new edition has changed with the times, focusing on what's most important in an electronic resumé full of successful resumé samples and cover letters, the books also focuses on the key words and phrases that will bring readers' resumés to the top of the HR pile. - More than 100 samples of real-life resumés and cover letters, many of them new - Founded in real-life experience without the rigid resumé-writing rules of other guides - Ideal for all job seekers, from new grads to the laid off worker, new mothers to senior citizens
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Legacy of the Lancasters
Young or old, everyone has heard of the Lancaster bomber. Such is the legacy handed down by this aviation icon that although it is not the most numerous aircraft ever built - two are still flying today, one in Britain and another in Canada with many proudly displayed in museums throughout the world - it is up there with the Spitfire and the Flying Fortress in terms of affection, nostalgia and lasting fame.The legendary Lancaster has bequeathed to the world an invaluable heritage beloved of generations of movie-goers, air show enthusiasts, readers of fine literature and historians alike. Exploits such as the famous low-level raid by 617 Squadron on Germanys hydro electric dams on the night of...
Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents
One of few books to cover all aspects of cyclin-dependent kinases (CDKs), this volume examines CDKs as molecular and functional entities, their role in various disease processes, and their potential for pharmacological modulation. The book first explains the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors. Then it examines the design, development, and chemistry of small molecule CDK inhibitors. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future prospects of CDK inhibitors as anticancer agents.
