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Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response
  • Language: en
  • Pages: 186

Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response

Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.

Current Perspectives, Challenges and Advances in Cell Based Therapies
  • Language: en
  • Pages: 192
AACR 2017 Proceedings: Abstracts 1-3062
  • Language: en
  • Pages: 3186

AACR 2017 Proceedings: Abstracts 1-3062

The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.

Co-signal Molecules in T Cell Activation
  • Language: en
  • Pages: 326

Co-signal Molecules in T Cell Activation

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.

Cancer Vaccines: Time to Think Differently!
  • Language: en
  • Pages: 284
Justice of the Peace and Local Government Review
  • Language: en
  • Pages: 894

Justice of the Peace and Local Government Review

  • Type: Book
  • -
  • Published: 1877
  • -
  • Publisher: Unknown

None

Combining chemo-radio therapy and immunotherapy for cancers—perfect mix of old and new
  • Language: en
  • Pages: 621
The Irish Countrywomen's Association
  • Language: en
  • Pages: 264

The Irish Countrywomen's Association

  • Type: Book
  • -
  • Published: 2000
  • -
  • Publisher: Unknown

None

50 Things You Need to Know About Periods
  • Language: en

50 Things You Need to Know About Periods

An essential, accessible resource championing period positivity It's time to talk about periods. Women are taught not to discuss them in public; the subject is still rife with stigma and shame. In this book, Claire shares 50 life skills to help understand the internal rhythm that women move through each month(ish). It allows the reader to discover the tools they need to work with their body, rather than pushing against it, and ultimately sync social life, exercise, self-care, holidays, budgeting, projects, and sex life around each phase of the menstrual cycle to enhance well-being. Brimming with clear instructions, self-care strategies, honest stories, and current research, this empowering book at once reassures, educates, and amuses.