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Engineering Translational Models of Lung Homeostasis and Disease
Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, m...
The Bitter Gourd Genome
This book focusing on the bitter gourd genome is the first comprehensive compilation of knowledge on the botany, cytogenetical analysis, genetic resources and diversity, traditional breeding, tissue culture and genetic transformation, whole genome sequencing and comparative genomics in the Cucurbitaceae family. It discusses the biochemical profile of the bioactives present in this horticultural crop, used both as a vegetable and as a medicine, and also addresses sex determination in bitter gourd. Written by respected international experts, the book is useful to students, teachers and scientists in academia, as well as seed companies and pharmaceutical industries.
Extracellular Matrix Degradation
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Proteases: Structure and Function
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role ...
Colonoscopy
First Edition - Winner of 2004 BMA Medical Book Competition in Gastroenterology The second edition of this prize winning book is written by some of the world's foremost experts in the field of colonoscopy and colonic imaging. Every chapter has been updated and 5 new chapters have been added to include the latest information and advances in the field of colonoscopy: Capsule Colonoscopy Narrow Band Imaging Confocal Endomicroscopy Endoscopic Submucosal Dissection in the Colon New Colonoscopes and Assist Devices Drawing on the vast experience of the authors it covers every area of medicine that impacts on colonoscopy, including virtual colonography, pathology, techniques for pediatric and adult ...
Human Cell Culture Protocols
A thoroughly revised and updated collection readily reproducible techniques for culturing human cells. This new edition includes a wide range of human cell types relevant to human disease and new chapters on fibroblasts, Schwann cells, gastric and colonic epithelial cells, and parathyroid cells. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Proteomic Profiling and Analytical Chemistry
Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detaile...
Physiological Pharmaceutics
In recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign material. This book provides an integrated approach to the study of drug formulation in the body with the emphasis on the formulation variables rather than the drugs. The link between physiology and pharmaceutics is presented to give an essential background of biological principles for the pharmacy student, pharmaceutical formulator and healthcare professional. Complex mathematical aspects of physical ...
